目的 探討鹽酸艾司氯胺酮注射液復(fù)合地佐辛注射液對剖宮產(chǎn)術(shù)后靜脈自控鎮(zhèn)痛（PCIA）產(chǎn)婦恢復(fù)質(zhì)量、康復(fù)情況的影響。方法 選取2021年12月—2022年4月桐城市人民醫(yī)院收治的80例美國麻醉醫(yī)師協(xié)會（ASA）Ⅰ～Ⅱ級單胎剖宮產(chǎn)產(chǎn)婦，根據(jù)隨機數(shù)字表法將所有患者分為對照組和治療組，每組各40例。對照組產(chǎn)婦給予枸櫞酸舒芬太尼注射液（2 μg/kg）＋地佐辛注射液（0.2 mg/kg）＋昂丹司瓊（8 mg）；治療組給予鹽酸艾司氯胺酮注射液（1 mg/kg）＋地佐辛注射液（0.2 mg/kg）＋昂丹司瓊（8 mg）。比較兩組術(shù)后40項恢復(fù)質(zhì)量量表（QoR40）評分、術(shù)后靜脈自控鎮(zhèn)痛有效按壓次數(shù)、首次下床活動時間、首次排氣時間、首次排尿時間、不良反應(yīng)的發(fā)生情況。結(jié)果 與對照組比較，術(shù)后24、48 h治療組舒適度評分、情緒狀態(tài)評分、心理支持評分、總評分均顯著升高，差異有統(tǒng)計學(xué)意義（P＜0.05）。治療組術(shù)后首次下床活動時間、首次排尿時間、首次排氣時間均明顯短于對照組，差異有統(tǒng)計學(xué)意義（P＜0.05）。兩組產(chǎn)婦頭暈、惡心嘔吐差異有統(tǒng)計學(xué)意義（P＜0.05）。結(jié)論 鹽酸艾司氯胺酮注射液復(fù)合地佐辛注射液用于產(chǎn)婦剖宮產(chǎn)術(shù)后PCIA，可產(chǎn)生良好的情緒和舒適度，提高早期恢復(fù)質(zhì)量，促進術(shù)后康復(fù)進程。

Objective To explore the effect of Esketamine Hydrochloride Injection combined with Dezocine Injection on the recovery quality and rehabilitation of parturients with patient-controlled intravenous analgesia (PCIA) after cesarean section. Methods Parturients (80 cases) with PCIA after cesarean section in the People's Hospital of Tongcheng from December 2021 to Apil 2022 were divided into control and treatment groups according to the random number table method, and each group had 40 cases. Patients in the control group were given Sufentanil Citrate Injection (2 μg/kg), Dezocine Injection (0.2 mg/kg), and ondansetron (8 mg). Patients in the treatment group were given Esketamine Hydrochloride Injection (1 mg/kg), Dezocine Injection (0.2 mg/kg), and ondansetron (8 mg). The QoR40 scores, effective pressing times of postoperative PCIA, first time out of bed activity time, first exhaust time, first urination time, and adverse reactions in two groups were compared. Results Compared with the control group, the comfort score, emotional state score, psychological support score, and total score of the treatment group were significantly increased at 24 h and 48 h after operation (P < 0.05). The first time of getting out of bed, the first time of urination, and the first time of exhaust in the treatment group was significantly shorter than those in the control group (P < 0.05). There was significant difference in dizziness, nausea, and vomiting between two groups (P < 0.05).Conclusion Esketamine Hydrochloride Injection combined with Dezocine Injection for PCIA after cesarean section can produce good mood and comfort, improve the quality of early recovery, and promote the process of postoperative rehabilitation.

R971