炎癥性腸病是一組慢性非特異性腸道炎癥性疾病，目前臨床上常用的傳統(tǒng)非靶向藥物可以緩解患者癥狀，但不能終止黏膜炎癥活動、疾病發(fā)展，且嚴(yán)重的不良反應(yīng)限制了這些藥物的應(yīng)用。納米顆粒由于其獨(dú)特的大小和物理特性，能夠通過黏液層將負(fù)載藥物傳遞到腸道細(xì)胞，也可以通過內(nèi)吞作用被巨噬細(xì)胞吞噬，從而調(diào)節(jié)腸道的免疫環(huán)境，此外，納米顆粒還具有改變藥物特性的潛力?？偨Y(jié)了治療炎癥性腸病的合成納米顆粒、天然納米顆粒的研究情況，以期為炎癥性腸病的治療帶來新的機(jī)遇。

Inflammatory bowel disease is a group of chronic non-specific intestinal inflammatory diseases. Traditional non-targeted drugs commonly used in clinic can relieve the symptoms of patients, but cannot stop mucosal inflammatory activities and disease development, and serious adverse reactions limit applications of these drugs. Due to its unique size and physical properties, nanoparticles can deliver loaded drugs to intestinal cells through the mucus layer, and can also be phagocytosed by macrophages through endocytosis to regulate the immune environment of the intestine. In addition, nanoparticles also have the potential to alter drug properties. This paper summarizes the research progress on synthetic nanoparticles and natural nanoparticles for the treatment of inflammatory bowel disease, hoping to bring new opportunities for the treatment of inflammatory bowel disease.

R975

甘肅省科技計(jì)劃項(xiàng)目(21YF5FA124)