骨關(guān)節(jié)炎是一種慢性退行性關(guān)節(jié)疾病，也是導致老年人慢性功能障礙的主要因素。二甲雙胍是目前公認用于治療糖尿病的一線藥物，可能也對骨關(guān)節(jié)炎軟骨具有保護作用。二甲雙胍抑制軟骨細胞炎癥反應、調(diào)節(jié)軟骨細胞代謝異常、影響軟骨細胞分化。對二甲雙胍治療骨關(guān)節(jié)炎的作用機制做一綜述，為二甲雙胍臨床應用提供參考。

Osteoarthritis is a chronic degenerative joint disease and a major factor to chronic dysfunction in the elderly. Metformin, currently recognized as the first-line drug for treatment of diabetes, may also have protective effects on cartilage in osteoarthritis. Metformin inhibits chondrocyte inflammatory response, regulates abnormal chondrocyte metabolism, and affects chondrocyte differentiation. This article reviews the mechanism of metformin in treatment of osteoarthritis, and provides a reference for the clinical application of metformin.

R966

遼寧省教育廳科學研究經(jīng)費項目（L202060）