目的 探討丹參多酚酸聯(lián)合尼麥角林治療急性腦梗死恢復(fù)期的臨床療效。方法 選取2019年6月—2021年12月在中國人民解放軍北部戰(zhàn)區(qū)總醫(yī)院治療的72例急性腦梗死恢復(fù)期患者，隨機將患者分為對照組和治療組，每組各36例。對照組口服尼麥角林片，20 mg/次，3次/d。在對照組的基礎(chǔ)上，治療組靜脈滴注注射用丹參多酚酸，0.13 g/次，加于生理鹽水250 mL中，1次/d。兩組連續(xù)治療14 d。觀察兩組患者臨床療效，比較治療前后兩組患者癥狀改善時間，美國國立衛(wèi)生研究院卒中量表（NIHSS）評分、日常生活活動能力（BI）評分，血清因子腫瘤壞死因子-α（TNF-α）、血管間黏附分子-1（VCAM-1）、白細胞介素-6（IL-6）和單核細胞趨勢蛋白-1（MCP-1）水平，及不良反應(yīng)情況。結(jié)果 治療后，治療組臨床有效率（97.22%）明顯高于對照組（75.00%，P＜0.05）。治療后，治療組癥狀改善時間均明顯早于對照組（P＜0.05）。治療后，兩組BI評分明顯升高，而NIHSS評分明顯下降（P＜0.05），且治療組BI和NIHSS評分明顯好于對照組（P＜0.05）。治療后，兩組血清因子IL-6、VCAM-1、TNF-α、MCP-1水平明顯降低（P＜0.05），且治療組明顯低于對照組（P＜0.05）。治療組不良反應(yīng)發(fā)生率（8.33%）明顯低于對照組（19.44%，P＜0.05）。結(jié)論 丹參多酚酸聯(lián)合尼麥角林治療急性腦梗死恢復(fù)期療效較好，可有效改善神經(jīng)功能損傷，增強日?；顒幽芰?，并能降低炎性因子。

Objective To explore the treatment effect of salvianolic acid combined with nicergoline in treatment of acute cerebral infarction in convalescent period.Methods Patients (72 cases) with acute cerebral infarction in convalescent period in General Hospital of Northern Theater Command from June 2019 to December 2021 were randomly divided into control and treatment group,and each group had 36 cases.Patients in the control group were po administered with Nicergoline Tablets,20 mg/time,three times daily.Patients in the treatment group were iv administered with Salvianolic Acid for injection on the basis of the control group,0.13 g/time added into normal saline 250 mL,once daily.Patients in two groups were treated for 14 d.After treatment,the clinical evaluation was evaluated,the improvement time of symptom,the scores of BI and NIHSS,the levels of serological IL-6,VCAM-1,TNF-α and MCP-1,adverse reactions in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group (97.22%) was significantly higher than that of the control group (75.00%,P<0.05).After treatment,the improvement time of symptom in the treatment group was significantly earlier than that in the control group (P<0.05).After treatment,the BI score of the two groups was significantly increased,while the NIHSS score was significantly decreased (P<0.05),and the BI and NIHSS scores of the treatment group were significantly better than those of the control group (P<0.05).After treatment,the levels of serum factors IL-6,VCAM-1,TNF-α and MCP-1 in two groups were significantly decreased (P<0.05),and which in the treatment group were significantly lower than those in the control group (P<0.05).The incidence of adverse reactions in the treatment group (8.33%) was significantly lower than that in the control group (19.44%,P<0.05).Conclusion Salvianolic acid combined with nicergoline have good therapeutic effects in treatment of acute cerebral infarction in convalescent stage,which can effectively improve the injury of neurological function,enhance the ability of daily activity and reduce inflammatory factors.

R971