目的 探討散風(fēng)通竅滴丸聯(lián)合布地奈德鼻噴霧劑治療慢性單純性鼻炎的臨床療效。方法 選取2020年1月—2022年1月天津市第四中心醫(yī)院收治180例慢性單純性鼻炎患者，隨機(jī)分對(duì)照組（90例）和治療組（90例）。對(duì)照組鼻吸入布地奈德鼻噴霧劑，每個(gè)鼻孔2噴，早晚各1次。在對(duì)照組的基礎(chǔ)上，治療組口服散風(fēng)通竅滴丸，20丸/次，3次/d。兩組用藥7 d。觀察兩組患者臨床療效，比較治療前后兩組患者癥狀緩解時(shí)間，嗅覺障礙評(píng)分，血清因子γ干擾素（IFN-γ）、白細(xì)胞介素-4（IL-4）、腫瘤壞死因子-α（TNF-α）和白細(xì)胞介素-17（IL-17）水平，及不良反應(yīng)情況。結(jié)果 治療后，治療組臨床有效率（97.78%）明顯高于對(duì)照組（86.67%，P＜0.05）。治療后，治療組鼻塞、打噴嚏、清鼻涕、嗅覺減低等好轉(zhuǎn)時(shí)間均早于對(duì)照組（P＜0.05）。治療后，兩組患者嗅覺障礙中氣味閾值、氣味識(shí)別、氣味鑒別評(píng)分明顯升高（P＜0.05）；且治療后，治療組改善優(yōu)于對(duì)照組（P＜0.05）。治療后，兩組血清因子IL-4、IL-17、TNF-α水平均明顯下降，而IFN-γ明顯升高（P＜0.05）；且治療后血清因子水平改善優(yōu)于對(duì)照組（P＜0.05）。治療組不良發(fā)生率（6.67%）明顯低于對(duì)照組（14.44%，P＜0.05）。結(jié)論 散風(fēng)通竅滴丸聯(lián)合布地奈德鼻噴霧劑治療慢性單純性鼻炎效果確切，能加快患者鼻塞等癥狀的改善，有效降低炎性因子，嗅覺功能恢復(fù)快。

Objective To investigate the clinical effect of Sanfeng Tongqiao Drop Pills combined with budesonide in treatment of chronic simple rhinitis.Methods Patients (180 cases) with chronic simple rhinitis in Tianjin Fourth Central Hospital from January 2020 to January 2022 were randomly divided into control (90 cases) and treatment (90 cases) group.Patients in the control group were administered with Budesonide Nasal Spray,2 sprays for each nostril,once in the morning and evening respectively.Patients in the treatment group were po administered with Sanfeng Tongqiao Drop Pills on the basis of the control group,20 pills/time,three times daily.Patients in two groups were treated for 7 d.After treatment,the clinical evaluation was evaluated,the relief time of symptom,the scores of olfactory disorder,the levels of serum factor IL-4,IL-17,TNF-α and IFN-γ,adverse reactions in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group (97.78%) was significantly higher than that of the control group (86.67%,P treatment of chronic simple rhinitis,which can accelerate the improvement of symptoms such as nasal congestion,effectively reduce inflammatory factors and restore olfactory function quickly.<0.05).After treatment,the improvement time of nasal congestion,sneezing,clear nose and decreased sense of smell in the treatment group was earlier than that in the control group (P<0.05).After treatment,the scores of odor threshold,odor recognition and odor discrimination in olfactory disorders in the two groups were significantly increased (P<0.05).After treatment,the improvement of the treatment group was better than that of the control group (P<0.05).After treatment,the levels of serum factors IL-4,IL-17 and TNF-α in the two groups were significantly decreased,while IFN-γ was significantly increased (P<0.05).The improvement of serum factor level after treatment was better than that of the control group (P<0.05).The incidence of adverse events in the treatment group (6.67%) was significantly lower than that in the control group (14.44%,P<0.05).Conclusion Sanfeng Tongqiao Drop Pills combined with Budesonide Nasal Spray is effective in the

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天津市衛(wèi)生健康委科技項(xiàng)目資助項(xiàng)目(ZC20163)