目的 探討頤和春口服液治療腎陽虛型不育癥的臨床療效。方法 選取2019年3月—2020年12月上海市第六人民醫(yī)院金山分院男科腎陽虛型不育癥患者100例，依據(jù)隨機數(shù)字表法將所有患者分為對照組和治療組，每組各50例。對照組給予常規(guī)西醫(yī)治療，治療組在對照組基礎上口服頤和春口服液，10 mL/次，3次/d。兩組患者連續(xù)治療12周。觀察兩組的臨床療效，比較精液理化特征指標和生殖激素水平的變化情況。結果 治療后，治療組總有效率是84.0%，顯著高于對照組的60.0%（P＜0.05）。治療后，兩組精子密度、A級精子密度、A＋B級精子密度均顯著高于治療前（P＜0.05）；治療后治療組精子密度、A級精子、A＋B級精子均顯著優(yōu)于對照組（P＜0.05）。治療后，兩組睪酮（T）水平呈現(xiàn)升高趨勢，促黃體生成素（LH）、促卵泡激素（FSH）、泌乳素（PRT）均呈現(xiàn)下降趨勢（P＜0.05），且治療后治療組血清生殖激素水平改善均顯著優(yōu)于對照組（P＜0.05）。結論 頤和春口服液治療不育癥屬腎陽虛的患者具有較好的臨床療效，可有效提高精子數(shù)量和精子活力，調(diào)節(jié)患者的血清生殖激素水平，值得臨床推廣。

Objective To explore the clinical effect of Yihechun Oral Liquid in treatment of kidney Yang deficiency type of infertility.Methods A total of 100 patients with kidney Yang deficiency type of infertility in the Andrology Department of Jinshan Branch of Shanghai Sixth People's Hospital from March 2019 to December 2020 were selected.According to the random number table method,all patients were divided into control group and treatment group,with 50 cases in each group.Patients in the control group were given conventional western medicine treatment.Patients in the treatment group were po administered with Yihechun Oral Liquid on the basis of the control group,10 mL/time,3 times daily.The two groups were treated for 12 weeks.The clinical efficacy of the two groups was observed,and the changes of semen physical and chemical characteristics and reproductive hormone levels were compared.Results After treatment,the total effective rate of the treatment group was 84.0%,which was significantly higher than that of the control group (60.0%,P<0.05).After treatment,the sperm density,grade A sperm density and grade A+B sperm density of the two groups were significantly higher than those before treatment (P<0.05).After treatment,the sperm density,grade A sperm and grade A+B sperm of the treatment group were significantly better than those of the control group (P<0.05).After treatment,the levels of testosterone (T) in the two groups showed an increasing trend,but the levels of luteinizing hormone (LH),follicle stimulating hormone (FSH) and prolactin (PRT) showed a decreasing trend (P<0.05).After treatment,the improvement of serum reproductive hormone levels in the treatment group was significantly better than that in the control group (P<0.05).Conclusion Yihechun Oral Liquid has a good clinical effect in treatment of kidney Yang deficiency type of infertility,and can effectively improve the sperm number and sperm motility,regulate the serum reproductive hormone level of patients,which is worthy of clinical promotion.

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