帕金森病是好發(fā)于中老年人的神經(jīng)退行性疾病。目前治療帕金森病的常用藥物是左旋多巴，但是患者在服用幾年之后會出現(xiàn)一系列的不良反應(yīng)。姜黃素是一種提取自姜黃科、天南星科等植物中的疏水性多酚類成分，在帕金森病的研究和治療中展現(xiàn)出潛在的療效。研究表明，姜黃素可以通過保護多巴胺能神經(jīng)元、抗炎、抗氧化、抗細胞凋亡、抗線粒體損傷、調(diào)節(jié)自噬等多種途徑在帕金森病中發(fā)揮神經(jīng)保護作用?？偨Y(jié)了姜黃素在帕金森病治療中涉及到的不同作用機制，為進一步開發(fā)安全可靠的藥物提供參考。

Parkinson's disease is a common neurodegenerative disease,which often occurs in the middle-aged and elderly.At present,the commonly used drug for the treatment of Parkinson's disease is levodopa,but patients will experience a series of adverse reactions after taking it for several years.Curcumin is a kind of hydrophobic polyphenols from plants such as Curcuminaceae and Araceae,which shows potential curative effect in the research and treatment of Parkinson's disease.Studies have shown that curcumin can play a neuroprotective role in Parkinson's disease by protecting dopaminergic neurons,anti-inflammatory,anti-oxidation,anti-apoptotic,anti-mitochondrial damage,and regulating autophagy and other pathways.This paper summarizes different mechanisms of curcumin in treatment of Parkinson's disease,and provides a reference for the development of safe and reliable drugs in the future.

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上海市中央引導(dǎo)地方科技發(fā)展資金項目(YDZX20213100001002)