結(jié)直腸癌是臨床常見(jiàn)消化系統(tǒng)惡性腫瘤，具有較高的發(fā)病率和死亡率。青蒿琥酯是從菊科植物黃花蒿中提取的青蒿素衍生物，除抗瘧作用外，可通過(guò)誘導(dǎo)細(xì)胞凋亡，抑制癌細(xì)胞增殖、侵襲和轉(zhuǎn)移，抑制新血管形成，促進(jìn)活性氧生成，抗炎，抗氧化應(yīng)激反應(yīng)發(fā)揮抗結(jié)直腸癌作用。探討青蒿琥酯抗結(jié)直腸癌的作用機(jī)制，為青蒿琥酯的臨床價(jià)值開(kāi)發(fā)提供依據(jù)。

Colorectal cancer is a common clinical malignant tumor of digestive system with high morbidity and mortality.Artesunate is an artemisinin derivative extracted from the Compositae plant Artemisia annua Linn.In addition to its antimalarial effect,artesunate can induce apoptosis,inhibit cancer cell proliferation,invasion,and metastasis,inhibit the formation of new blood vessels,and promote reactive oxygen species generation,anti-inflammatory,and anti-oxidative stress to exert anti-colorectal cancer effects.This article discusses the mechanism of artesunate against colorectal cancer,hoping to provide evidence for the clinical value of artesunate.

R977

江西省衛(wèi)生計(jì)生委科技計(jì)劃課題(20172214)