目的 探討清開靈注射液聯(lián)合注射用頭孢西丁鈉治療急性上呼吸道感染的臨床療效。方法 選取2020年2月—2022年1月秦皇島市中醫(yī)醫(yī)院收治的76例急性上呼吸道感染患者，全部患者按照隨機數(shù)字表法分為對照組和治療組，每組各38例。對照組患者靜脈滴注注射用頭孢西丁鈉，2g加入100mL生理鹽水中，2次/d。治療組患者在對照組治療的基礎(chǔ)上靜脈滴注清開靈注射液，20mL加入100mL葡萄糖液中，1次/d。兩組患者連續(xù)治療7d。觀察兩組的臨床療效，比較兩組的主要癥狀的消失時間、血清白細胞介素-18（IL-18）、C反應(yīng)蛋白（CRP）、白細胞（WBC）水平。結(jié)果 治療后，治療組的總有效率為97.37%，高于對照組的總有效率81.58%，差異有統(tǒng)計學意義（P＜0.05）。治療后，治療組患者的體溫復(fù)常時間、咳嗽消失時間、咽部紅腫消失時間均短于對照組，差異有統(tǒng)計學意義（P＜0.05）。治療后，兩組患者的血清IL-18、CRP、WBC水平顯著降低（P＜0.05）；治療組的血清IL-18、CRP、WBC水平低于對照組，差異有統(tǒng)計學意義（P＜0.05）。結(jié)論 清開靈注射液聯(lián)合注射用頭孢西丁鈉治療急性上呼吸道感染具有較好的臨床療效，能緩解臨床癥狀，減輕炎癥反應(yīng)，藥物安全性良好。

Objective To investigate the clinical efficacy of Qingkailing Injection combined with Cefoxitin Sodium for injection in treatment of acute upper respiratory tract infection. Methods Patients (76 cases) with acute upper respiratory tract infection in Qinhuangdao Hospital of Traditional Chinese Medicine from February 2020 to January 2022 were divided into control and treatment groups according to random number table method, and each group had 38 cases. Patients in the control group were iv administered with Cefoxitin Sodium for injection, 2g added into glucose solution 100 mL, twice daily. Patients in the treatment group were iv administered with Qingkailing Injection on the basis of the control group, 20 mL added into glucose solution 100 mL, once daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and the disappearance times of main symptoms, and the serum levels of IL-18, CRP, and WBC in two groups were compared. Results After treatment, the total effective rate of the treatment group was 97.37%, which was higher than that of the control group (81.58%), and the difference was statistically significant (P<0.05). After treatment, the temperature normalization time, cough disappearance time, and pharyngeal swelling disappearance time of the treatment group were shorter than those of the control group, and the difference was statistically significant (P<0.05). After treatment, the serum levels of IL-18, CRP, and WBC in two groups were significantly decreased (P<0.05). The serum levels of IL-18, CRP, and WBC in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Qingkailing Injection combined with Cefoxitin Sodium for injection has clinical curative effect in treatment of acute upper respiratory tract infection, can alleviate clinical symptoms and inflammatory reaction, with good safety.

R974

秦皇島市市級科學技術(shù)研究與發(fā)展計劃項目（202004A125）