目的 探討補腎益腦丸聯(lián)合甲鈷胺治療耳鳴的臨床療效。方法 選取2018年12月—2021年7月南陽市中心醫(yī)院收治的94例耳鳴患者，使用隨機數(shù)字表法將所有患者分為對照組和治療組，每組各47例。對照組口服甲鈷胺片，0.5mg/次，3次/d。治療組在對照組基礎上口服補腎益腦丸，10丸/次，2次/d。兩組療程均為2周。觀察兩組的臨床療效，比較治療前后兩組耳鳴持續(xù)時間評分、耳鳴響度視覺模擬量表（VAS）評分及耳鳴障礙問卷（THQ）、普通話版的耳鳴問卷表（MTQ）、醫(yī)院焦慮和抑郁量表（HADS）總分。結果 治療后，治療組總有效率是89.4%，顯著高于對照組的72.3%（P＜0.05）。治療后，兩組耳鳴持續(xù)時間評分和耳鳴響度VAS評分均顯著低于治療前（P＜0.05）；且均以治療組降低更顯著（P＜0.05）。治療后，兩組THQ、MTQ和HADS總分均顯著降低（P＜0.05）；且治療組降低更顯著（P＜0.05）。結論 補腎益腦丸聯(lián)合甲鈷胺對耳鳴患者具有確切的臨床療效，能安全有效地緩解患者耳鳴癥狀，減輕耳鳴的不良影響，提高生活質(zhì)量，改善消極情緒。

Objective To analyze the clinical efficacy of Bushen Yinao Pills combined with mecobalamin in treatment of tinnitus. Methods A total of 94 tinnitus patients admitted to Nanyang Central Hospital from December 2018 to July 2021 were selected. All patients were divided into control group and treatment group by random number table method, with 47 cases in each group. Patients in the control group were po administered with Mecobalamin Tablets, 0.5 mg/time, three times daily. Patients in the treatment group were po administered with Bushen Yinao Pills on the basis of the control group, 10 pills/time, twice daily. Both groups were treated for 2 weeks. The clinical efficacy of the two groups was observed. The tinnitus duration score, tinnitus loudness visual analogue scale (VAS) score, Tinnitus disorder Questionnaire (THQ), Mandarin Tinnitus Questionnaire (MTQ), the total scores of Hospital Anxiety and Depression Scale (HADS) were compared between the two groups before and after treatment. Results After treatment, the total effective rate of the treatment group was 89.4%, which was significantly higher than that of the control group (72.3%) (P<0.05). After treatment, the tinnitus duration score and tinnitus loudness VAS score in the two groups were significantly lower than those before treatment (P<0.05). And the reduction was more significant in the treatment group (P<0.05). After treatment, the total scores of THQ, MTQ, and HADS in the two groups were significantly decreased (P<0.05). And the treatment group decreased more significantly (P<0.05). Conclusion Bushen Yinao Pills combined with mecobalamin has a definite clinical effect in treatment of tinnitus, and can safely and effectively relieve the symptoms of tinnitus, reduce the adverse effects of tinnitus, improve the life quality, which can improve negative emotions.

R987

南陽市衛(wèi)生和計劃生育委員會科研項目（ZD201798）