侵襲性念珠菌感染已成為備受關(guān)注的公共衛(wèi)生問題，而現(xiàn)行治療念珠菌感染的藥物有限，聯(lián)合用藥是一種實用有效的新藥開發(fā)策略。從天然植物（尤其是藥用植物）中提取的化合物及其衍生物與傳統(tǒng)的抗真菌劑聯(lián)合使用對殺滅念珠菌具有顯著的協(xié)同作用。歸納了念珠菌對傳統(tǒng)抗真菌藥物的耐藥情況，并總結(jié)了中藥協(xié)同傳統(tǒng)抗真菌藥物的抑菌活性和抑菌機制，以期為抗念珠菌新型治療策略的研究提供參考依據(jù)。

Invasive Candida infection has become a public health issue of great concern. However, the current drugs for treatment of Candida infection are limited, and drug combination is a practical and effective new drug development strategy. The combination of compounds and their derivatives extracted from natural plants (especially medicinal plants) and traditional antifungal agents has significant synergistic effect on killing Candida. This article summarized the resistance of Candida against traditional antifungal drugs, and summarized the antibacterial activity of traditional Chinese medicine combination with traditional antifungal drugs, to clarify the antibacterial mechanism, in order to provide a reference for new treatment strategies of drugs against Candida.

R978

國家自然科學(xué)基金資助項目（82003817）