子癇前期是妊娠期特發(fā)疾病，是新生兒和產(chǎn)婦發(fā)病和死亡的主要原因，因此探索安全有效的預(yù)防和治療藥物是重要途徑。二甲雙胍在妊娠早期是安全的，沒有先天畸形的風(fēng)險(xiǎn)，可以作為一種治療子癇前期有前景的候選藥物。二甲雙胍通過促進(jìn)血管生成和保護(hù)內(nèi)皮細(xì)胞、抗炎和抑制氧化應(yīng)激、對抵抗危險(xiǎn)因素的滋養(yǎng)細(xì)胞保護(hù)作用而對子癇前期具有防治作用，同時(shí)二甲雙胍可以降低孕婦發(fā)生子癇前期的風(fēng)險(xiǎn)，延長早產(chǎn)子癇前期孕婦的妊娠期。因此總結(jié)了二甲雙胍防治子癇前期的作用機(jī)制和臨床研究，以期為二甲雙胍臨床上治療子癇前期提供參考。

Preeclampsia is an idiopathic disease in pregnancy, which is the leading cause of neonatal and maternal morbidity and mortality, and exploring safe and effective preventive and therapeutic drugs is an important way. Metformin is safe in early pregnancy, without the risk of congenital malformation, and can be used as a promising candidate drug for treatment of preeclampsia. Metformin can prevent and treat preeclampsia by promoting angiogenesis, protecting endothelial cells, anti-inflammatory, inhibiting oxidative stress, and protecting trophoblasts against risk factors. In the same time, metformin can reduce the risk of preeclampsia in pregnant women and prolong the pregnancy period of preterm preeclampsia pregnant women. This article reviewed the mechanism and clinical research of metformin in prevention and treatment of preeclampsia, hoping to provide a reference for metformin in clinical treatment of preeclampsia.

R984

國家臨床重點(diǎn)?？平ㄔO(shè)目標(biāo)（晉衛(wèi)辦醫(yī)函[2021]113號）；山西醫(yī)科大學(xué)第一醫(yī)院院基金項(xiàng)目（YY2215）