口腔惡性腫瘤是頭頸部常見病變，是發(fā)生于口腔部位的惡性腫瘤總稱，包括牙齦癌、口咽癌、唇癌、舌癌、口腔鱗狀細(xì)胞癌等?？谇粣盒阅[瘤在臨床上多采用綜合治療手段。姜黃素是從姜黃、郁金中提取的活性成分，可以通過誘導(dǎo)細(xì)胞凋亡、抑制細(xì)胞增殖、降低腫瘤細(xì)胞侵襲力、誘導(dǎo)細(xì)胞自噬、抗氧化作用、抗炎作用、抗口腔纖維化、提高放化療療效等多種途徑發(fā)揮顯著的抗口腔癌作用。對姜黃素防治口腔惡性腫瘤的作用機(jī)制進(jìn)行綜述，以期為姜黃素的臨床運(yùn)用提供參考。

Oral malignant tumor is a common pathological change of head and neck, and it is a general term for malignant tumors that occur in the oral cavity, including gum cancer, oropharyngeal cancer, lip cancer, tongue cancer, oral squamous cell carcinoma, etc. Oral malignant tumors are mostly treated with comprehensive treatment in clinical. Curcumin is the active ingredient from Curcumae Longae Rhizoma and Curcumae Radix, which can play a significant anti-cancer effect by inducing apoptosis, inhibiting cell proliferation, reducing tumor cell invasiveness, inducing autophagy, anti-oxidation, anti-inflammatory, anti-oral fibrosis, improving the curative effect of chemoradiotherapy and other ways. This paper reviews the mechanism of curcumin in prevention and treatment of oral malignant tumors, hoping to provide a reference for the clinical application of curcumin.

R988.2;R979.1

河北省衛(wèi)生健康委醫(yī)學(xué)科學(xué)研究課題計(jì)劃（20171377）