膿毒癥相關(guān)性急性腎損傷目前被認(rèn)為是與膿毒癥相關(guān)的最嚴(yán)重并發(fā)癥之一，病理生理機(jī)制仍不明確。右美托咪定是一種新型高效的α₂腎上腺素受體激動(dòng)劑。在膿毒癥中，右美托咪定可通過抗炎、抗氧化應(yīng)激、增強(qiáng)自噬調(diào)節(jié)、影響血流動(dòng)力學(xué)來保護(hù)腎臟功能，因此就右美托咪定對(duì)膿毒癥腎臟功能的保護(hù)作用的研究進(jìn)展進(jìn)行了綜述。

Sepsis-associated acute kidney injury is currently considered as one of the most serious complications associated with sepsis, and its pathophysiological mechanism is still unclear. Dexmedetomidine is a novel and efficient α₂-adrenergic receptor agonist. In sepsis, dexmedetomidine may protect kidney function by anti-inflammatory, anti-oxidative stress, enhancing autophagy regulation, and affecting hemodynamics. This article reviews the research progress on protection of dexmedetomidine on renal function in sepsis.

R971