目的 探討清宣止咳顆粒聯(lián)合頭孢克洛顆粒治療兒童慢性支氣管炎的臨床療效。方法 選取2020年5月-2021年12月在郴州市第一人民醫(yī)院就診的90例慢性支氣管炎患兒,根據(jù)隨機(jī)數(shù)字表法將所有患兒分為對照組和治療組,每組各45例。對照組使用30mL左右溫水沖服頭孢克洛顆粒,20 mg/kg,分3次服用。治療組在對照組治療的基礎(chǔ)上溫水沖服清宣止咳顆粒,3次/d,1~3歲,0.5袋/次,4~6歲,0.75袋/次,7~14歲,1袋/次。兩組患兒連續(xù)治療7 d。觀察兩組的臨床療效,比較兩組癥狀消失時(shí)間、氧合指數(shù)、血氧分壓、血氧飽和度和血清中白細(xì)胞介素-6(IL-6)、前白蛋白(PA)、腫瘤壞死因子-α(TNF-α)水平。結(jié)果 治療后,治療組的總有效率為95.56%,明顯高于對照組的總有效率82.22%,組間差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,治療組患兒咳嗽、肺啰音、咯痰、喘息消失時(shí)間均短于對照組(P<0.05)。治療后,兩組的氧合指數(shù)、血氧分壓、血氧飽和度較治療前顯著升高(P<0.05),治療組氧合指數(shù)、血氧分壓、血氧飽和度明顯高于對照組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組的血清IL-6、TNF-α水平低于治療前,血清PA水平高于治療前(P<0.05);治療組血清IL-6、TNF-α水平低于對照組,血清PA水平高于對照組(P<0.05)。結(jié)論 清宣止咳顆粒聯(lián)合頭孢克洛顆粒治療兒童慢性支氣管炎的療效確切,可減輕臨床癥狀,改善血?dú)庵笜?biāo),降低炎癥反應(yīng),且安全性良好。

Objective To investigate the clinical effect of Qingxuan Zhike Granules combined with Cefaclor Granules in treatment of chronic bronchitis in children. Methods Children (90 cases) with chronic bronchitis in Chenzhou First People’s Hospital from May 2020 to December 2021 were divided into control and treatment groups according to random number table method, and each group had 45 cases. Patients in the control group were po administered with Cefaclor Granules by about 30 mL warm water, 20 mg/kg, taken with three times. Patients in the treatment group were po administered with Qingxuan Zhike Granules on the basis of the control group, three times daily, 0.5 bag for 1-3 years old, 0.75 bag for 4-6 years old, and 1 bag for 7-14 years old. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and symptom disappearance time, oxygenation index, blood oxygen partial pressure and blood oxygen saturation, the levels of IL-6, PA, and TNF-α in two groups were compared. Results After treatment, the total effective rate of the treatment group was 95.56%, which was significantly higher than 82.22% of the control group (P＜0.05). After treatment, the disappearance times of cough, pulmonary rale, expectoration, and wheezing in the treatment group were shorter than those in the control group (P＜0.05). After treatment, the oxygenation index, blood oxygen partial pressure, and blood oxygen saturation of two groups were significantly higher than those before treatment (P＜0.05). The oxygenation index, blood oxygen partial pressure, and blood oxygen saturation of the treatment group were significantly higher than those of the control group (P＜0.05). After treatment, the serum levels of IL-6 and TNF-α in two groups were lower than those before treatment, but the serum level of PA was higher than those before treatment (P＜0.05). The serum levels of IL-6 and TNF-α in the treatment group were lower than those in the control group, but the serum level of PA in the treatment group was higher than those in the control group (P＜0.05). Conclusion Qingxuan Zhike Granules combined with Cefaclor Granules has definite efficacy in treatment of chronic bronchitis in children, can reduce clinical symptoms, improve blood gas indicators, and reduce inflammatory reaction, with good safety.

R974

湘南學(xué)院2021年度校級科研項(xiàng)目(2021XJ133)