目的 探討小兒感冒舒顆粒聯(lián)合頭孢克肟治療小兒急性細(xì)菌性上呼吸道感染的臨床療效。方法 選取2021年1月-2022年5月中國(guó)人民解放軍聯(lián)勤保障部隊(duì)第九四一醫(yī)院收治的126例急性細(xì)菌性上呼吸道感染患兒,按隨機(jī)數(shù)字表法將所有患者分為對(duì)照組和治療組,每組各63例。對(duì)照組溫開(kāi)水沖服頭孢克肟顆粒,體質(zhì)量<30 kg患兒每次3 mg/kg,體質(zhì)量 ≥ 30 kg患兒100 mg/次,2次/d。治療組在對(duì)照組基礎(chǔ)上溫開(kāi)水沖服小兒感冒舒顆粒,1~3歲患兒3 g/次,4次/d;4~7歲患兒6 g/次,3次/d;8~12歲患兒6 g/次,4次/d。兩組均連續(xù)治療5 d。觀(guān)察兩組臨床療效,比較兩組退熱效果和局部典型表現(xiàn)消失時(shí)間。比較治療前后兩組白細(xì)胞計(jì)數(shù)(WBC)、中性粒細(xì)胞百分比(NEUT%)異常率,紅細(xì)胞沉降率(ESR)及血清降鈣素原(PCT)、C反應(yīng)蛋白(CRP)水平。結(jié)果 治療后,治療組患兒總有效率是92.31%,顯著高于對(duì)照組的84.13%(P<0.05)。治療組即刻退熱率47.6%較對(duì)照組30.2%顯著提高,退熱起效時(shí)間、完全退熱時(shí)間均顯著短于對(duì)照組(P<0.05)。治療后,治療組咽痛、鼻塞、流涕、咳嗽消失時(shí)間較對(duì)照組均顯著縮短(P<0.05)。與治療前相比,兩組治療后WBC、NEUT%異常率均顯著降低(P<0.05);且治療后,治療組WBC、NEUT%異常率均顯著低于對(duì)照組(P<0.05)。治療后,兩組ESR和血清PCT、CRP水平均較治療前顯著下降(P<0.05);且均以治療組降低更顯著(P<0.05)。結(jié)論 小兒感冒舒顆粒聯(lián)合頭孢克肟治療小兒急性細(xì)菌性上感的總體療效確切,能迅速緩解患兒癥狀,促進(jìn)外周血象恢復(fù),有效減輕機(jī)體感染及炎性損傷,且患兒耐受性較好。

Objective To investigate the clinical efficacy of Xiaoer Ganmaoshu Granules combined with cefixime in treatment of children with acute bacterial upper respiratory tract infection. Methods A total of 126 children with acute bacterial upper respiratory tract infection admitted to 941 Hospital of Joint Logistic Support Force of Chinese People’s Liberation Army from January 2021 to May 2022 were selected. All children were divided into control group and treatment group according to random number table method, with 63 cases in each group. Children in the control group were po administered with Cefixime Granules with warm boiled water, body weight＜30 kg were given 3 mg/kg each time, and children with body weight ≥30 kg were given 100 mg/time, twice daily. Children in the treatment group were and C-reactive protein (CRP) levels were compared between the two groups before and after treatment. Results After treatment, the total effective rate of the treatment group was 92.31%, which was significantly higher than that of the control group (84.13%, P＜0.05). The immediate antipyretic rate of the treatment group was 47.6%, which was significantly higher than that of the control group (30.2%). The antipyretic onset time and complete antipyretic time of the treatment group were significantly shorter than those of the control group (P＜0.05). After treatment, the disappearance time of sore throat, nasal obstruction, runny nose and cough in the two groups was significantly shorter than that in the control group (P＜0.05). Compared with before treatment, the abnormal rates of WBC and NEUT% in the two groups were significantly decreased after treatment (P＜0.05). After treatment, the abnormal rates of WBC and NEUT% in the treatment group were significantly lower than those in the control group (P＜0.05). After treatment, the levels of ESR, serum PCT and CRP in the two groups were significantly decreased compared with those before treatment (P＜0.05). And the reduction was more significant in the treatment group (P＜0.05). Conclusion Xiaoer Ganmaoshu Granules combined with cefixime has a definite overall effect in treatment of acute bacterial infection in children, and can quickly relieve the symptoms of children, promote the recovery of peripheral blood, effectively reduce the infection and inflammatory damage of the body with good tolerance. po administered with Xiaoer Ganmaoshu Granules with warm boiled water on the basis of the control group, 3 g/time, 4 times daily for children aged 1-3 years. Children aged 4-7 years were given 6 g/time, 3 times daily. Children aged 8-12 years were given 6 g/time, 4 times daily. Both groups were treated for 5 d. The clinical efficacy of the two groups was observed. The antipyretic effect and the disappearance time of local typical manifestations were compared between the two groups. The abnormal rate of white blood cell count (WBC), neutrophil percentage (NEUT%), erythrocyte sedimentation rate (ESR), serum procalcitonin (PCT)

R914

西寧市衛(wèi)生健康委指導(dǎo)性計(jì)劃課題(2021-wjzdx-79)