目的 探討三金片聯(lián)合鹽酸洛美沙星治療急性腎盂腎炎的臨床療效。方法 選擇2020年3月-2022年3月在鄭州市第七人民醫(yī)院腎病科治療的80例急性腎盂腎炎患者,隨機(jī)分為對(duì)照組(40例)和治療組(40例)。對(duì)照組患者靜脈滴入鹽酸洛美沙星注射液,0.2 g/次,2次/d。治療組在對(duì)照組的基礎(chǔ)上口服三金片,3片/次,3次/d。兩組治療7 d。觀察兩組患者臨床療效,比較治療前后兩組患者癥狀緩解時(shí)間,血清尿素氮(BUN)、血清肌酐(Cr)、血清胱抑素C(CysC)指標(biāo)水平,血清降鈣素(PCT)、腫瘤壞死因子-α(TNF-α)、白細(xì)胞介素-6(IL-6)、C反應(yīng)蛋白(CRP)水平,及不良反應(yīng)。結(jié)果 治療后,治療組臨床有效率(97.50%)明顯高于對(duì)照組療效率(77.50%,P<0.05)。治療后,治療組癥狀緩解時(shí)間均短于對(duì)照組(P<0.05)。治療后,兩組患者BUN、Cr、CysC、IL-6、PCT、TNF-α、CRP水平均明顯降低(P<0.05),且治療組患者明顯低于對(duì)照組(P<0.05)。治療組不良反應(yīng)發(fā)生率為7.50%,明顯低于對(duì)照組(17.50%,P<0.05)。結(jié)論 三金片聯(lián)合鹽酸洛美沙星治療急性腎盂腎炎效果確切,明顯緩解患者癥狀,改善腎功能狀態(tài),降低局部炎性反應(yīng)。

Objective To investigate the clinical effect of Sanjin Tablets combined with lomefloxacin hydrochloride in treatment of acute pyelonephritis. Methods Patients (80 cases) with acute pyelonephritis in the 7th People's Hospital of Zhengzhou from March 2020 to March 2022 were randomly divided into control (40 cases) and treatment (40 cases) group. Patients in the control group were iv administered with Lomefloxacin Hydrochloride Injection, 0.2 g/time, twice daily. Patients in the treatment group po administered with Sanjin Tablets on the basis of the control group, 3 tablets/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical evaluation was evaluated, the relief time of symptom, the levels of BUN, Cr, CysC, IL-6, PCT, TNF-α and CRP, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group (97.50%) was significantly higher than that of the control group (77.50%, P＜0.05). After treatment, the time of symptom relief in the treatment group was earlier than that in the control group (P＜0.05). After treatment, the levels of BUN, Cr, CysC, IL-6, PCT, TNF-α and CRP in two groups were significantly decreased (P＜0.05), and which in the treatment group were significantly lower than those in the control group (P＜0.05). The incidence of adverse reactions in the treatment group was 7.50%, which was significantly lower than that in the control group (17.50%, P＜0.05). Conclusion Sanjin Tablets combined with lomefloxacin hydrochloride is effective in the treatment of acute pyelonephritis, which can obviously relieve the symptoms, improve the renal function and reduce the local inflammatory reaction.

R914

河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃(聯(lián)合共建)項(xiàng)目(LHCJ20191125)