目的 探討痛經(jīng)寧顆粒聯(lián)合布洛芬緩釋片治療原發(fā)性痛經(jīng)的臨床療效。方法 選取2020年3月-2022年5月天津市寧河區(qū)醫(yī)院收治的118例原發(fā)性痛經(jīng)患者,按隨機(jī)數(shù)字表法分為對(duì)照組和治療組,每組各59例。對(duì)照組口服布洛芬緩釋片,1片/次,2次/d。治療組在對(duì)照組基礎(chǔ)上口服痛經(jīng)寧顆粒,1袋/次,2次/d。兩組患者經(jīng)前7 d開(kāi)始連續(xù)治療5 d。觀察兩組的臨床療效,比較疼痛程度、痛經(jīng)癥狀和血清指標(biāo)水平。結(jié)果 治療后,治療組的總有效率96.61%明顯高于對(duì)照組的總有效率84.75%(P<0.05)。治療后,兩組的NRS評(píng)分均顯著降低(P<0.05),且治療組的NRS評(píng)分低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組的痛經(jīng)發(fā)作頻次、每次持續(xù)時(shí)間均顯著減少(P<0.05),且治療組痛經(jīng)發(fā)作頻次、每次持續(xù)時(shí)間明顯少于對(duì)照組(P<0.05)。治療后,兩組的血清5-羥色胺(5-HT)、前列腺素F2α(PGF2α)、白細(xì)胞介素-10(IL-10)水平顯著降低(P<0.05);治療組的血清5-HT、PGF2α、IL-10水平低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 痛經(jīng)寧顆粒聯(lián)合布洛芬緩釋片治療原發(fā)性痛經(jīng)的療效確切,能減輕疼痛程度和痛經(jīng)癥狀,降低血清指標(biāo)水平。

Objective To investigate the clinical effect of Tongjingning Granules combined with Ibuprofen Sustained-release Tablets in treatment of primary dysmenorrhea. Methods Patients (118 cases) with primary dysmenorrhea in Ninghe District Hospital of Tianjin from March 2020 to May 2022 were divided into control and treatment groups according to random number table method, and each group had 59 cases. Patients in the control group were po administered with Ibuprofen Sustained-release Tablets, 1 tablet/time, twice daily. Patients in the treatment group were po administered with Tongjingning Granules on the basis of the control group, 1 bag/ time, twice daily. Patients in two groups were treated for 5 d from 7 d before menstruation. After treatment, the clinical efficacies were evaluated, and the degree of pain, dysmenorrhea symptom, and serum indicators in two groups were compared. Results After treatment, the total effective rate of the treatment group (96.61%) was significantly higher than 84.75% of the control group (P＜0.05). After treatment, the NRS scores of two groups were significantly decreased (P＜0.05), and the NRS scores of the treatment group were lower than those of the control group (P＜0.05). After treatment, the frequency and duration of dysmenorrhea in two groups were significantly decreased (P＜0.05), and the frequency and duration of dysmenorrhea in the treatment group were significantly lower than those in the control group (P＜0.05). After treatment, the serum levels of 5-HT, PGF2α, and IL-10 in two groups were significantly decreased (P＜0.05). The serum levels of 5-HT, PGF2α, and IL-10 in the treatment group were lower than those in the control group P＜0.05). Conclusion Tongjingning Granules combined with Ibuprofen Sustained-release Tablets is effective in treatment of primary dysmenorrhea, which can reduce the degree of pain and dysmenorrhea symptoms, and reduce the level of serum indicators.

R972

天津市教委科研計(jì)劃項(xiàng)目(自然科學(xué))(2019KJ047)