目的 分析免疫檢查點(diǎn)抑制劑致膀胱炎發(fā)生的特點(diǎn)及規(guī)律,為臨床合理用藥提供參考。方法 檢索中國知網(wǎng)、萬方、維普、PubMed、Web of Science數(shù)據(jù)庫,收集2011年3月-2022年10月關(guān)于免疫檢查點(diǎn)抑制劑致膀胱炎報道的文獻(xiàn),提取數(shù)據(jù)并進(jìn)行分析。結(jié)果 共納入15篇免疫檢查點(diǎn)抑制劑致膀胱炎個案報道,涉及患者16例,平均年齡(56.5±8.16)歲,原發(fā)疾病為肺癌的患者最多(56.25%),膀胱炎發(fā)生時間多為用藥后1~6個周期。14例經(jīng)停藥和(或)激素治療后好轉(zhuǎn)。結(jié)論 免疫檢查點(diǎn)抑制劑致膀胱炎多發(fā)生在用藥1~6個治療周期后,涉及多個年齡段患者,應(yīng)及時識別免疫檢查點(diǎn)抑制劑相關(guān)性膀胱炎,盡早給予相應(yīng)處理和治療,保障患者用藥安全。

Objective To analyze the characteristics and regularity of cystitis caused by immune checkpoint inhibitors, and to provide reference for clinical rational drug use. Methods The databases of CNKI, Wanfang, VIP, PubMed, and Web of Science were searched, and the literatures about cystitis caused by immune checkpoint inhibitors from March 2011 to October 2022 were collected, and the data were extracted and analyzed. Results A total of 15 case reports of cystitis caused by immune checkpoint inhibitors were included, involving 16 patients. The average age was (56.5 ± 8.16) years old, and the primary disease was lung cancer (56.25%). Cystitis usually occurs 1-6 cycles after medication. 14 cases improved after drug withdrawal and/or hormone therapy. Conclusion Cystitis caused by immune checkpoint inhibitors mostly occurs after 1-6 cycles of medication, involving patients of multiple age groups. Identify the cystitis associated with immune checkpoint inhibitors in time, give corresponding treatment and treatment as soon as possible to ensure the safety of patients’ medication.

R979.1

湖北省衛(wèi)生健康委中醫(yī)藥科研立項(xiàng)項(xiàng)目(ZY2021Q007)