[關(guān)鍵詞]
[摘要]
人工精子激活基礎(chǔ)研究和臨床輔助生殖技術(shù)治療中應(yīng)用最廣泛的精子激活因子為非選擇性磷酸二酯酶(PDE)抑制劑。利用非選擇性PDE抑制劑處理精子能夠全面抑制PDE的活性,通過加強(qiáng)胞內(nèi)環(huán)磷酸腺苷(cAMP)信號(hào)來提升精子運(yùn)動(dòng)能力。基于人工精子激活的重要作用靶點(diǎn)PDE,綜述了3種常用非選擇性PDE抑制劑咖啡因、己酮可可堿和茶堿對(duì)人精子運(yùn)動(dòng)的激活效應(yīng)的研究進(jìn)展,為非選擇性PDE抑制劑用于人工精子激活提供參考。
[Key word]
[Abstract]
Non-selective phosphodiesterase (PDE) inhibitor is the most widely used sperm activating factor in basic research of artificial sperm activation and clinical treatment of assisted reproductive technology. Treatment of sperm with non-selective PDE inhibitors can comprehensively inhibit the activity of PDE, and enhance sperm motility by enhancing intracellular cAMP signal. Based on the important target PDE of artificial sperm activation, this paper reviewed the research progress of the activation effect of three commonly used non-selective PDE inhibitors, caffeine, pentoxifylline, and theophylline, on human sperm motility, providing a reference for the application of non-selective phosphodiesterase inhibitors in artificial sperm activation.
[中圖分類號(hào)]
R983
[基金項(xiàng)目]
柳州市人民醫(yī)院引進(jìn)高層次人才科研啟動(dòng)基金項(xiàng)目(LRYGCC202208);柳州市人民醫(yī)院院內(nèi)科研項(xiàng)目(lry202011)
