目的 培養(yǎng)鹽酸去甲金霉素的單晶，進(jìn)行結(jié)構(gòu)表征。方法 用水培養(yǎng)單晶，使用熱重法（TGA）、粉末X射線衍射（PXRD）、單晶X射線衍射（SXRD）檢測(cè)分析。結(jié)果 制備的鹽酸去甲金霉素為無(wú)色粒狀晶體，晶胞屬于單斜晶系，空間群為P2₁，分子式為C₂₁H₂₁ClN₂O₈·HCl·3H₂O，相對(duì)分子質(zhì)量為555.35，晶體密度為1.593 mg/mm³，絕對(duì)構(gòu)型為S,S,S,S,S構(gòu)型。結(jié)論 證明了鹽酸去甲金霉素的立體構(gòu)型，培養(yǎng)的晶體晶型為三水合物。

Objective To cultivate single crystal of demeclocycline hydrochloride, and to characterize its structure. Methods Cultivate single crystals with water, and TGA, PXRD, and SXRD were used to detect and analyze. Results Demeclocycline hydrochloride colorless granular crystal was obtained. Crystal in demeclocycline hydrochloride was confirmed to be monoclinic lattice with space group P2₁. Moreover, the chemical formula and relative molecular mass were C₂₁H₂₁ClN₂O₈·HCl·3H₂O and 555.35. Crystal density were 1.593 mg/mm³, and absolute configuration was (S,S,S,S,S). Conclusion Crystal structure of demeclocycline hydrochloride is characterized, and the crystal form is demeclocycline hydrochloride trihydrate.

R914

工業(yè)與信息化部化學(xué)原料藥環(huán)保安全技術(shù)服務(wù)平臺(tái)項(xiàng)目（2020-0107-3-1）