肺癌是全球惡性腫瘤相關(guān)死亡的主要原因之一，手術(shù)、化療、放療等傳統(tǒng)癌癥治療方法是臨床治療肺癌的主要手段，但患者中位生存期未發(fā)生明顯提高。川芎嗪是川芎中主要活性成分，具有多種藥理作用。川芎嗪可誘導(dǎo)腫瘤細(xì)胞凋亡，抑制腫瘤血管形成，抑制腫瘤細(xì)胞增殖、侵襲和轉(zhuǎn)移，提高化療藥物敏感性，調(diào)節(jié)細(xì)胞免疫功能，通過(guò)多途徑、多機(jī)制對(duì)肺癌細(xì)胞增殖、轉(zhuǎn)移、侵襲、細(xì)胞凋亡發(fā)揮防治作用。因此綜述了川芎嗪防治肺癌的作用機(jī)制，為肺癌的臨床治療提供參考。

Lung cancer is one of the main causes of global malignancy related death. Surgery, radiotherapy, and chemotherapy are the main means of clinical treatment of lung cancer, but the median survival time of patients has not been significantly improved. Ligustrazine is the main active ingredient in Chuanxiong Rhizoma, which has a variety of pharmacological effects. Ligustrazine could induce tumor cell apoptosis, inhibit tumor angiogenesis, inhibit tumor cell proliferation, invasion, and metastasis, improve chemotherapeutic drug sensitivity, and regulate cellular immune function. Ligustrazine plays a preventive and therapeutic role in the proliferation, metastasis, invasion, and apoptosis of lung cancer through multiple pathways and mechanisms. This article reviews the mechanism of ligustrazine in prevention and treatment of lung cancer and provides reference for clinical treatment of lung cancer.

R979.1