目的 觀察金剛藤膠囊聯(lián)合布洛芬治療原發(fā)性痛經(jīng)的臨床療效。方法 選擇2019年6月—2021年12月在安徽理工大學(xué)第一附屬醫(yī)院就診的96例原發(fā)性痛經(jīng)患者，按照隨機(jī)數(shù)字表法分為對(duì)照組（48例）和治療組（48例）。對(duì)照組經(jīng)前2～3 d口服布洛芬緩釋膠囊，1粒/次，2次/d。治療組在對(duì)照組基礎(chǔ)上口服金剛藤膠囊，4粒/次，3次/d。兩組患者連續(xù)治療3個(gè)月經(jīng)周期。觀察兩組患者臨床療效，比較治療前后兩組患者疼痛評(píng)分，血清β-內(nèi)啡肽、前列腺素E₂（PGE₂）、P物質(zhì)（SP）和血小板活化因子（PAF）水平。結(jié)果 治療后，治療組的總有效率（93.75%）明顯高于對(duì)照組（75.00%，P＜0.05）。治療后，兩組患者疼痛總頻率評(píng)分和嚴(yán)重程度評(píng)分明顯下降（P＜0.05），且治療組明顯低于對(duì)照組（P＜0.05）。治療后，兩組血清β-內(nèi)啡肽水平明顯升高，而PGE₂、SP和PAF水平明顯下降（P＜0.05），且治療組改善程度明顯好于對(duì)照組（P＜0.05）。結(jié)論 金剛藤膠囊聯(lián)合布洛芬治療原發(fā)性痛經(jīng)，可有效減輕疼痛癥狀，改善血清PGE₂、SP、PAF、β-內(nèi)啡肽水平。

Objective To observe the clinical effect of Jingangteng Capsules combined with ibuprofen in treatment of primary dysmenorrhea. Methods Patients (96 cases) with primary dysmenorrhea in the First Hospital of Anhui University of Science & Technology from June 2019 to December 2021 were divided into control (48 cases) and treatment (48 cases) group by the random number table method. Patients in the control group was po administered with Ibuprofen Sustained-Release Capsules 2 — 3 d before menstruation, 1 grain/time, twice daily. Patients in the treatment group were po administered with Jingangteng Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 3 menstrual cycles. After treatment, the clinical evaluation was evaluated, and the pain scores, the levels of serum β-Endorphin, PGE₂, SP, and PAF in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group (93.75%) was significantly higher than that of the control group (75.00%, P < 0.05). After treatment, the total frequency score and severity score of pain in two groups were significantly decreased (P < 0.05), and which in the treatment group were significantly lower than that in the control group (P < 0.05). After treatment, the level of serum β-endorphin in two groups was significantly increased, while the levels of PGE₂, SP, and PAF were significantly decreased (P < 0.05), and these indicators in the treatment group were significantly better than that in the control group (P < 0.05). Conclusion Jingangteng Capsules combined with ibuprofen in treatment of primary dysmenorrhea can effectively relieve pain symptoms and improve the levels of serum PGE2, SP, PAF and β-endorphin.

R984