目的 通過注射用血栓通（凍干）及同類中藥注射劑文獻情況，找準臨床定位，并為正式文獻檢索提供思路。方法 在參與注射用血栓通（凍干）臨床應用專家共識的編制工作時，按照中華中醫(yī)藥學會標準化辦公室的標準流程，將“文獻預檢索”運用在構(gòu)建臨床問題步驟中，對注射用血栓通（凍干）及同類中藥注射劑文獻發(fā)表情況、注射用血栓通（凍干）及相同有效成分中藥系統(tǒng)評價/Meta分析、注射用血栓通（凍干）說明書臨床適應證的相關(guān)指南/專家共識中成藥納入情況及相關(guān)指南推薦用藥方案情況4方面進行文獻預檢索。結(jié)果 注射用血栓通（凍干）發(fā)表的文獻總量與同類中成藥相比較少，在文獻發(fā)表方面無明顯優(yōu)勢。建議結(jié)合權(quán)威專家訪談和大樣本的臨床調(diào)研，獲取權(quán)威專家的用藥經(jīng)驗及臨床醫(yī)生最廣泛關(guān)注的用藥問題，以彌補證據(jù)不足情況。結(jié)論 對注射用血栓通（凍干）文獻預檢索在構(gòu)建臨床問題中的應用和實踐做重點介紹，以期為中成藥臨床應用專家共識工作的開展提供借鑒。

Objective Through the literature of Xueshuantong for injection (freeze-dried) and similar traditional Chinese medicine injections, the clinical positioning was identified, and the ideas for formal literature retrieval were provided. Methods When participating in the preparation of expert consensus on the clinical application of Xueshuantong for injection (freeze-dried), according to the standard process of Standardization Office of China Association of Traditional Chinese Medicine, “l(fā)iterature pre-search” was applied in the process of constructing clinical problems. For injection via blood clots (lyophilization) and similar Chinese medicine injection literatures published results, for injection via blood clots (lyophilization) and the same active ingredients evaluation/Meta analysis of traditional Chinese medicine system, injection with thrombosis (lyophilization) instruction clinical indications related guide/expert consensus proprietary Chinese medicine into the situation and related guidelines recommend regimen in four aspects, such as literature retrieval. Results Xueshuantong for injection (freeze-dried) has less literature publication than similar proprietary Chinese medicine, so it has no obvious advantage in literature publication. It is suggested to combine authoritative expert interviews and large sample clinical research to obtain the medication experience of authoritative experts and the medication problems most widely concerned by clinicians, so as to make up for the lack of evidence. Conclusions The application and practice of Xueshuantong for injection (freeze-dried) literature pre-search in the construction of clinical problems are mainly introduced, in order to provide reference for the development of expert consensus on clinical application of proprietary Chinese medicine.

R972

天津市高等學校“創(chuàng)新團隊培養(yǎng)計劃”（TD13-5047）