[關(guān)鍵詞]
[摘要]
慢性心力衰竭是一種常見(jiàn)的心血管疾病,也是終末期和最主要的死亡原因之一。芪參益氣滴丸由黃芪、三七、丹參、降香等組成,共奏益氣活血、通絡(luò)行氣、化瘀止痛的功效,可用于治療射血分?jǐn)?shù)降低的心力衰竭、射血分?jǐn)?shù)保留的心力衰竭和缺血性心力衰竭,其作用機(jī)制與抗炎癥反應(yīng),減少心肌纖維化、抑制心室重構(gòu),調(diào)節(jié)氧化應(yīng)激,促進(jìn)血管新生,抑制心肌細(xì)胞凋亡,調(diào)節(jié)免疫功能密切相關(guān)。鑒于此,對(duì)芪參益氣滴丸治療不同類型慢性心力衰竭的臨床療效及其作用機(jī)制研究進(jìn)展進(jìn)行綜述,為慢性心力衰竭的治療提供參考。
[Key word]
[Abstract]
Chronic heart failure is a common cardiovascular disease and one of the most common end-stage and major causes of death. Qishen Yiqi Dropping Pills is a combination of Astragali Radix, Notoginseng Radix et Rhizoma, Salviae Miltiorrhizae Radix, Lignum Dalbergiae Odoriferae, and other traditional Chinese medicine, which can benefit qi, promote blood circulation, channel qi, remove blood stasis, and relieve pain. Qishen Yiqi Dropping Pills can be used to treat heart failure with reduced ejection fraction, heart failure with preserved ejection fraction, and ischemic heart failure. The mechanism of Qishen Yiqi Dropping Pills is closely related to anti-inflammatory reaction, reducing myocardial fibrosis, inhibiting ventricular remodeling, regulating oxidative stress, promoting angiogenesis, inhibiting cardiomyocyte apoptosis, and regulating immune function. This article reviews the clinical efficacy and its mechanism of Qishen Yiqi Dropping Pills in treatment of different types of chronic heart failure, providing reference for the treatment of chronic heart failure.
[中圖分類號(hào)]
R285.6
[基金項(xiàng)目]
天津市“131”創(chuàng)新型人才培養(yǎng)工程項(xiàng)目(2016)