目的 探討芩翹口服液聯(lián)合頭孢克肟治療小兒急性扁桃體炎的臨床療效。方法 選取2019年6月—2022年6月東營市東營區(qū)人民醫(yī)院收治的96例急性扁桃體炎患兒,按隨機數(shù)字表法將所有患者分為對照組和治療組,每組各48例。對照組口服頭孢克肟顆粒,體質(zhì)量<30 kg者,每次3 mg/kg,2次/d;體質(zhì)量≥30 kg者,100 mg/次,2次/d。治療組在對照組基礎(chǔ)上口服芩翹口服液,1~4歲者,5 mL/次,3次/d;5~7歲者,8 mL/次,3次/d;8~12歲者,10 mL/次,3次/d。兩組療程均為5 d。觀察兩組臨床療效,比較治療前后兩組典型癥狀積分、兒童睡眠習慣問卷(CSHQ)總分、兒童生活質(zhì)量普適性核心量表4.0(PedsQL4.0)總分及血清C反應(yīng)蛋白(CRP)、血清淀粉樣蛋白A(SAA)和降鈣素原(PCT)水平。統(tǒng)計兩組不良反應(yīng)情況。結(jié)果 治療后,治療組總有效率為97.92%,顯著高于對照組的87.50%(P<0.05)。治療后,兩組咽痛積分、咽干灼熱積分、發(fā)熱積分、扁桃體腫大積分、喉核黏膜充血積分均顯著降低(P<0.05),均以治療組下降更顯著(P<0.05)。治療后,兩組CSHQ總分均顯著降低,而PedsQL4.0總分均顯著增加(P<0.05),均以治療組改善更顯著(P<0.05)。治療后,兩組血清CRP、SAA、PCT水平均顯著下降(P<0.05),均以治療組降低更顯著(P<0.05)。治療過程中,治療組和對照組不良反應(yīng)發(fā)生率分別是6.25%、4.17%,兩組不良反應(yīng)發(fā)生率比較差異無統(tǒng)計學意義。結(jié)論 芩翹口服液聯(lián)合頭孢克肟治療小兒急性扁桃體炎可獲得滿意療效,能安全有效地緩解患兒臨床癥狀,促進睡眠質(zhì)量與生活質(zhì)量的改善,顯著降低機體感染程度,減輕炎性損傷。

Objective To investigate the clinical effect of Qinqiao Oral Liquid combined with cefixime in treatment of acute tonsillitis in children.Methods A total of 96 children with acute tonsillitis admitted to Dongying District People's Hospital of Dongying City from June 2019 to June 2022 were selected and divided into control group and treatment group according to random number table method, with 48 cases in each group. Patients in the control group were po administered with Cefixime Granules, body weight < 30kg, 3 mg/kg each time, twice daily, body weight ≥ 30 kg, 100 mg/time, twice daily. Patients in the treatment group were po administered with Qinqiao Oral Liquid on the basis of the control group, 1 — 4 years old, 5 mL/time, 3 times daily, 5 — 7 years old, 8 mL/time, 3times daily, 8 — 12 years old, 10 mL/time, 3 times daily. The treatment course of both groups was 5 d. The clinical efficacy of the two groups was observed, and the typical symptom scores, the total score of children's Sleep Habits Questionnaire(CSHQ), the total score of children's Quality of Life Universal Core Scale 4.0(PedsQL4.0), the serum C-reactive protein(CRP), serum amyloid protein A(SAA), and procalcitonin(PCT) levels of the two groups were compared before and after treatment. The adverse reactions of the two groups were analyzed.Results After treatment, the total effective rate of the treatment group was 97.92%, which was significantly higher than that of the control group(87.50%, P<0.05). After treatment, pharyngeal pain score, pharyngeal dry burning score, fever score, tonsil enlargement score and throat nucleus mucosal congestion score were significantly decreased in two groups(P<0.05), and they were more significantly decreased in the treatment group(P<0.05). After treatment, the total score of CSHQ was significantly decreased in both groups, while the total score of PedsQL4.0 was significantly increased(P<0.05), and the improvement was more significant in the treatment group(P<0.05). After treatment, serum CRP, SAA and PCT levels in two groups were significantly decreased(P<0.05), and they were more significantly decreased in the treatment group(P<0.05). During the treatment, the incidence of adverse reactions in the treatment group and the control group was 6.25% and 4.17%, respectively, and there was no statistical significance in the incidence of adverse reactions between the two groups.Conclusion Qinqiao Oral Liquid combined with cefixime has satisfactory efficacy in treatment of acute tonsillitis in children, and can safely and effectively relieve the clinical symptoms of children, promote the improvement of sleep quality and quality of life, and can significantly reduce the degree of body infection, which can reduce inflammatory injury.

R985; R987

山東省醫(yī)藥衛(wèi)生科技發(fā)展計劃項目(2019WS042)