目的 探討婦血康顆粒聯(lián)合米索前列醇片治療產(chǎn)后出血的臨床療效。方法 選擇2019年3月—2021年2月濟南市第二婦幼保健院收治的96例產(chǎn)后出血患者,根據(jù)信封抽簽法將患者分為對照組和治療組,每組各48例。對照組患者飯前口服米索前列醇片,0.6 mg/次,1次/d。治療組在對照組的基礎(chǔ)上開水沖服婦血康顆粒,10 g/次,3次/d。兩組均連續(xù)治療7 d。觀察兩組的臨床療效,比較兩組的2、24 h出血量與止血時間、凝血功能指標和血清一氧化氮(NO)、血清抗凝血酶-Ⅲ(ATⅢ)水平。結(jié)果 治療后,治療組患者的治愈率(91.67%)高于對照組治愈率(66.67%),組間比較差異具有顯著性(P<0.05)。治療后,治療組2、24 h出血量少于對照組,止血時間短于對照組(P<0.05)。治療后,兩組凝血酶原時間(PT)、活化部分凝血酶原時間(APTT)、凝血酶時間(TT)均顯著下降,纖維蛋白原(FIB)升高(P<0.05),且治療組PT、APTT、TT均明顯低于對照組,FIB高于對照組(P<0.05)。治療后,兩組NO水平下降,AT-Ⅲ水平升高(P<0.05);治療后,治療組NO水平低于對照組,AT-Ⅲ水平高于對照組(P<0.05)。結(jié)論 婦血康顆粒聯(lián)合米索前列醇片治療產(chǎn)后出血的止血效果良好,可有效改善機體凝血功能指標和NO、AT-Ⅲ水平,具有良好的臨床應(yīng)用價值。

Objective To investigate the clinical efficacy of Fuxuekang Granules combined with Misoprostol Tablets in treatment of postpartum hemorrhage.Methods Patients(96 cases) with postpartum hemorrhage in the Second Children & Women's Healthcare of Jinan City from March 2019 to February 2021 were divided into control and treatment groups according to the envelope drawing method, and each group had 48 cases. Patients in the control group were po administered with Misoprostol Tablets before dinner, 0.6mg/time, once daily. Patients in the treatment group were po administered with Fuxuekang Granules on the basis of the control group,10 g/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and amount of bleeding and time to stop bleeding at 2 h and 24 h, the coagulation function indexes, the serum levels of NO and AT-Ⅲ in two groups were compared.Results After treatment, the cure rate of the treatment group(91.67%) was higher than that of the control group(66.67%) with significant difference(P<0.05). After treatment, the blood loss at 2 h and 24 h in the treatment group was less than that in the control group, and the time of hemostasis in the treatment group was shorter than that in the control group(P<0.05).After treatment, PT, APTT, and TT in two groups were significantly decreased, but FIB were significantly increased(P<0.05). And PT, APTT, and TT in the treatment group were significantly lower than those in the control group, but FIB were significantly higher than those in the control group(P<0.05). After treatment, the levels of NO in two groups were decreased, but the levels of AT-Ⅲ in two groups were increased(P<0.05). After treatment, the levels of NO in the treatment group were lower than those in the control group, but the levels of AT-Ⅲ in the treatment group were higher than those in the control group(P<0.05).Conclusion Fuxuekang Granules combined with Misoprostol Tablets have good hemostatic effect in treatment of postpartum hemorrhage, can effectively improve the coagulation function indexes and the levels of NO and AT-Ⅲ, which has good clinical application value.

R984

山東省醫(yī)藥衛(wèi)生科技發(fā)展計劃項目(20204040136)