目的 探討龍血竭片聯(lián)合塞來昔布膠囊治療血瘀型腰椎間盤突出癥的臨床療效。方法 選取2022年1月—2022年6月天津市北辰醫(yī)院收治的100例血瘀型腰椎間盤突出癥患者,隨機分為對照組和治療組,每組各50例。對照組患者口服塞來昔布膠囊,0.2 g/次,1次/d。治療組患者在對照組基礎上口服龍血竭片,6片/次,3次/d。兩組患者均治療14 d。觀察兩組患者臨床療效,比較治療前后兩組患者視覺模擬評分法(VAS)、日本骨科協(xié)會評估治療分數(shù)(JOA)和Oswestry功能障礙指數(shù)(ODI)評分,及超氧化物歧化酶(SOD)、丙二醛(MDA)、腫瘤壞死因子-α(TNF-α)、白細胞介素-1(IL-1)和白細胞介素-6(IL-6)水平。結果 治療后,治療組總有效率顯著高于對照組(96.00%vs 84.00%,P<0.05)。治療后,兩組患者VAS和ODI評分顯著低于治療前,而JOA評分顯著高于治療前(P<0.05);且治療組各項評分顯著好于對照組(P<0.05)。治療后,兩組患者MDA水平顯著降低,而SOD水平顯著升高(P<0.05),且治療組患者氧化應激水平顯著好于對照組(P<0.05)。治療后,兩組患者TNF-α、IL-1和IL-6水平顯著低于治療前(P<0.05),且治療組患者炎癥因子水平顯著低于對照組(P<0.05)。結論 龍血竭片聯(lián)合塞來昔布膠囊治療腰椎間盤突出癥的療效和安全性均較高,能有效減輕氧化應激和炎性反應,緩解腰腿疼痛以及改善腰椎功能。

Objective To investigate the effect of Longxuejie Tablets and celecoxib in treatment of lumbar disc herniation.Methods Patients(100 cases) with lumbar disc herniation in Tianjin Beichen Hospital from January 2022 to June 2022 were randomly divided into control and treatment group, and each group had 50 cases. Patients in the control group were po administered with Celecoxib Capsules,0.2 g/time, once daily. Patients in the treatment group were po administered with Longxuejie Tablets on the basis of the control group,6 tablets/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical evaluation was evaluated,and the scores of VAS, ODI and JOA, and the levels of MDA, SOD, TNF-α, IL-1 and IL-6 in two groups before and after treatment were compared.Results After treatment, the clinical effective rate of the treatment group was significantly higher than that of the control group(96.00% vs 84.00%, P<0.05). After treatment, the scores of VAS and ODI in two groups were significantly lower than those before treatment, while the score of JOA was significantly higher, and the scores in the treatment group were significantly better than those in the control group(P<0.05). After treatment, the level of MDA in two groups was significantly decreased, while the level of SOD was significantly increased, and the level of oxidative stress in the treatment group was significantly better than that in the control group(P<0.05). After treatment, the levels of TNF-α, IL-1 and IL-6 in two groups were significantly lower than those before treatment, and which in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Longxuejie Tablets combined with Celecoxib Capsules has high efficacy and safety in the treatment of lumbar disc herniation, which can effectively reduce oxidative stress and inflammatory reaction, relieve waist and leg pain and improve lumbar function.

R977