目的 探討美他多辛聯(lián)合納美芬治療急性酒精中毒的臨床療效及安全性。方法 回顧性選取2020年1月—2022年8月合肥市第三人民醫(yī)院收治的140例急性酒精中毒患者為研究對象,采用SPSS 22.0進(jìn)行傾向性評分匹配成功80例,分為對照組和治療組,每組各40例。對照組靜脈滴注鹽酸納美芬注射液,0.2~0.4 mg加入生理鹽水250~500 mL。治療組在對照組基礎(chǔ)上靜脈滴注美他多辛注射液,600~900 mg加入生理鹽水250~500 mL。觀察兩組患者臨床療效,比較治療前后兩組患者癥狀消失時間、蘇醒時間和住院時間,及氧化應(yīng)激指標(biāo)谷胱甘肽(GSH)、丙二醛(MDA)和超氧化物歧化酶(SOD)水平。結(jié)果 治療后,治療組患者臨床有效率顯著高于對照組患者(97.50%vs 80.00%,P<0.05)。治療后,治療組患者癥狀消失時間、蘇醒時間和住院時間均明顯短于對照組患者(P<0.05)。治療后,兩組患者GSH、SOD水平均明顯高于治療前,MDA水平明顯低于治療前(P<0.05),且治療組患者氧化應(yīng)激指標(biāo)水平顯著優(yōu)于對照組患者(P<0.05)。結(jié)論 對于急性酒精中毒患者,在鹽酸納美芬治療的基礎(chǔ)上給予美他多辛注射液的臨床療效更為滿意,能夠有效減輕酒精中毒對機(jī)體氧化應(yīng)激反應(yīng)的影響,且藥物安全性好。

Objective To study the clinical efficacy and safety of metadoxine combined with nalmefene in treatment of acute alcoholism.Methods 140 patients with acute alcoholism in the Third People's Hospital of Hefei from January 2020 to August 2022were selected retrospectively. 80 patients of successful matching of propensity score with SPSS 22.0, and they were divided into control and treatment group, and each group had 40 cases. Patients in the control group was iv administered with Nalmefene Hydrochloride Injection, 0.2 — 0.4 mg added into normal saline 250 — 500 mL. Patients in the treatment group were iv administered with Metadoxine Injection on the basis of the control group, 600 — 900 mg added into normal saline 250 — 500 mL. After treatment, the clinical evaluation was evaluated, and the time of symptoms disappearance, awakening and hospitalization, and the oxidative stress indicators of GSH, MDA and SOD in two groups before and after treatment were compared.Results After treatment, the clinical effective rate of patients in the treatment group was significantly higher than that in the control group(97.50% vs 80.00%, P<0.05). After treatment,the disappearance time of symptoms, awakening time and hospital stay in the treatment group was significantly shorter than those in the control group(P<0.05). After treatment, the levels of GSH and SOD in two groups were significantly higher than those before treatment, while the level of MDA was significantly lower than that before treatment(P<0.05), and the level of oxidative stress index in the treatment group was significantly better than that in the control group(P<0.05).Conclusion For patients with acute alcoholism,the clinical effect of metadoxin injection on the basis of nalmefen hydrochloride is more satisfactory, which can effectively reduce the effect of alcoholism on oxidative stress, and the drug safety is good.

R977

安徽醫(yī)科大學(xué)?？茖W(xué)研究基金資助項目(2021xkj125)