抑郁癥已成為嚴(yán)重的全球健康問題。以化學(xué)藥物為主的臨床治療方案呈現(xiàn)出不同程度的不良反應(yīng)和耐藥性。植物多糖來源豐富,是研究最廣泛的一種多糖類物質(zhì),具有抗氧化、抗腫瘤、抗炎、抗衰老、抗抑郁等多種生物活性。植物多糖可以通過調(diào)節(jié)神經(jīng)遞質(zhì)及其受體表達(dá)、炎癥反應(yīng)、下丘腦-垂體-腎上腺軸、神經(jīng)營養(yǎng)因子、抗氧化應(yīng)激損傷以及調(diào)節(jié)色氨酸代謝、腸道菌群發(fā)揮抗抑郁作用。植物多糖結(jié)構(gòu)與抗抑郁功效關(guān)系的大多數(shù)研究僅僅停留在描述其單糖組成,單糖在植物多糖抗抑郁功效中發(fā)揮的作用還未涉及。因此就植物多糖的抗抑郁作用機(jī)制、相關(guān)信號通路以及構(gòu)效關(guān)系進(jìn)行綜述,為用于抗抑郁植物多糖產(chǎn)品的開發(fā)提供參考。

Depression has become a serious global health problem. Clinical use of chemical drugs for treatment presents varying degrees of adverse reactions and drug resistance. As one of the most widely studied polysaccharides, plant polysaccharides are rich in sources and have various biological activities such as anti-oxidation, anti-tumor, anti-inflammation, anti-aging, anti-depression and other effects. Plant polysaccharides play an anti-depression role by regulating the expression of neurotransmitters and their receptors,inflammatory response, hypothalamic-pituitary-adrenal axis(HPA), neurotrophic factors, antioxidant stress injury, and regulating tryptophan metabolism and intestinal flora. Most studies on the relationship between the structure of plant polysaccharides and their antidepressant effects have only focused on describing their monosaccharide composition, and the role of monosaccharides in the antidepressant effects of plant polysaccharides is not yet known. This article reviews the antidepressant mechanisms, related signaling pathways, and structure-activity relationships of plant polysaccharides, hoping to provide reference for the development of antidepressant plant polysaccharide products.

R971

國家大豆產(chǎn)業(yè)技術(shù)體系(CARS-04-PS29);三亞中國農(nóng)業(yè)科學(xué)院國家南繁研究院南繁專項(xiàng)(YYLH05);中國農(nóng)業(yè)科學(xué)院基本科研業(yè)務(wù)費(fèi)專項(xiàng)院級統(tǒng)籌項(xiàng)目(Y2022LM09);中國農(nóng)業(yè)科學(xué)院農(nóng)產(chǎn)品加工研究所創(chuàng)新工程(CAAS-ASTIP-2023-IFST)