松果體被認(rèn)為是晝夜節(jié)律的神經(jīng)內(nèi)分泌轉(zhuǎn)換器,以高度晝夜節(jié)律的方式產(chǎn)生褪黑素,發(fā)揮其抗氧化、抗腫瘤、延緩衰老等生物學(xué)功能,傳播晝夜節(jié)律的信息。當(dāng)松果體受損后,褪黑素分泌量下降,會(huì)引起患者神經(jīng)過(guò)度興奮、免疫力降低、抗氧化能力降低等一系列表現(xiàn)。專門(mén)制備松果體損傷的動(dòng)物模型的研究報(bào)道很少,化學(xué)性因素、物理性因素和綜合因素均可致大鼠松果體損傷,可用于制備松果體損傷的動(dòng)物模型。因此總結(jié)了松果體損傷動(dòng)物模型的制備方法,為建立方法簡(jiǎn)便、成模時(shí)間短的松果體損傷模型提供依據(jù)。

Pineal is considered as the neuroendocrine converter of circadian rhythm. It produces melatonin in a highly circadian rhythm way, exerts its biological functions, such as anti-oxidation, anti-tumor, and anti-aging, and spreads the information of Circadian rhythm.When pineal is damaged, the secretion of melatonin decreases, which will cause a series of symptoms such as overexcitation of nerves,decreased immunity, and reduced antioxidant capacity. There are few studies on the specific preparation of pineal damage model.Chemical factors, physical factors, and comprehensive factors can cause damage to pineal of rats, which can be used to prepare animal models of pineal damage. In this paper, the preparation methods of animal models of pineal injury were summarized, which provided a basis for the establishment of a simple and rapid pineal injury model.

R965.1

山西省自然科學(xué)基金面上項(xiàng)目(201901D111427);山西省衛(wèi)生健康委員會(huì)“四個(gè)一批”科技興醫(yī)創(chuàng)新計(jì)劃項(xiàng)目(2020SYS06)