乳腺癌是影響全球女性的最常見惡性腫瘤之一,化療藥物的耐藥性已成為乳腺癌治療中最常見的挑戰(zhàn)之一。樺木酸是一種天然存在的三萜類化合物,具有多種藥理作用。樺木酸能通過(guò)抑制乳腺癌腫瘤細(xì)胞增殖和生長(zhǎng)、促使腫瘤細(xì)胞凋亡、抑制腫瘤細(xì)胞侵襲和轉(zhuǎn)移、抑制炎癥反應(yīng)以及與其他藥物協(xié)同抗腫瘤等多個(gè)作用機(jī)制發(fā)揮抗乳腺癌的作用,因此綜述了樺木酸抗乳腺癌的作用機(jī)制,以期為樺木酸的臨床使用提供參考。

Breast cancer is one of the most common malignant tumors affecting women worldwide, and the drug resistance of chemotherapy has become one of the most common challenges in the treatment of breast cancer. Betulinic acid is a naturally occurring triterpenoid compound with various pharmacological effects. Betulinic acid can play an anti-tumor role in breast cancer by inhibiting the proliferation and growth of tumor cells, promoting the apoptosis of tumor cells, inhibiting the invasion and metastasis of tumor cells, inhibiting inflammatory reaction, and playing a synergistic anti-tumor role with other drugs and other mechanisms. This article reviews the mechanism of betulinic acid against breast cancer, in order to provide reference for the clinical use of betulinic acid.

R979.1

邢臺(tái)市科技計(jì)劃項(xiàng)目(2019ZC345)