良性前列腺增生是影響男性泌尿系統(tǒng)健康的常見病變。姜黃素是從姜黃中提取的二酮類化合物,具有多種功效,臨床廣泛用于多種疾病的治療。姜黃素可通過抑制核因子-κB信號(hào)通路激活和炎癥因子的分泌,促進(jìn)前列腺間質(zhì)細(xì)胞凋亡,抑制前列腺細(xì)胞上皮-間充質(zhì)轉(zhuǎn)化進(jìn)程,抑制前列腺組織中生長因子的表達(dá)等多種途徑抑制前列腺增生和減輕前列腺炎的炎癥反應(yīng)。對(duì)姜黃素防治前列腺良性病變的作用機(jī)制進(jìn)行綜述,為姜黃素的臨床運(yùn)用提供參考。

Benign prostatic hyperplasia is a common disease affecting the health of male urinary system. Curcumin is a diketone compound extracted from Curcumae Longae Rhizoma. It has many effects and is widely used in treatment of many diseases. Curcumin can inhibit prostatic hyperplasia and reduce the inflammatory reaction of prostatitis in a variety of ways, such as inhibit activation of NF-κB signaling pathway and secretion of inflammatory factors, promote apoptosis of prostate stromal cells, inhibit the epithelialmesenchymal transformation process of prostate cells, inhibit the expression of growth factors in prostate tissue, and other multiple pathways inhibit prostate hyperplasia and alleviate the inflammatory response of prostatitis. This article reviews the mechanism of curcumin in prevention and treatment of benign prostatic diseases, and provides a reference for the clinical application of curcumin.

R983

天津市衛(wèi)生健康科技項(xiàng)目(zc20163)