目的 探討地衣芽孢桿菌活菌顆粒聯(lián)合頭孢克洛治療小兒急性細(xì)菌性腸炎的臨床療效。方法 選擇2022年1月-2022年11月在南通市海門區(qū)人民醫(yī)院治療的細(xì)菌性腸炎患兒80例,隨機分為對照組(40例)和治療組(40例)。對照組口服頭孢克洛干混懸劑,0.125 g/次,3次/d。在對照組治療基礎(chǔ)上,治療組口服地衣芽孢桿菌活菌顆粒,0.5袋/次,3次/d。兩組患兒治療5 d。觀察兩組患兒臨床療效,比較治療前后兩組患兒癥狀好轉(zhuǎn)時間,外周血白細(xì)胞(WBC)、中性粒細(xì)胞(NE)水平,血清炎性因子降鈣素原(PCT)、血清淀粉樣蛋白(SAA)、肌酸激酶同工酶(CK-MB)、C反應(yīng)蛋白(CRP)水平,及不良反應(yīng)情況。結(jié)果 治療后,治療組臨床有效率(97.51%)明顯高于對照組有效率(82.50%,P<0.05)。治療后,治療組癥狀好轉(zhuǎn)時間均早于對照組(P<0.05)。治療后,兩組患兒外周血WBC、NE、CK-MB、SAA、PCT、CRP水平均明顯降低(P<0.05),且治療組明顯低于對照組(P<0.05)。治療后,治療組不良反應(yīng)發(fā)生率為7.51%,明顯低于對照組(17.50%,P<0.05)。結(jié)論 地衣芽孢桿菌活菌顆粒聯(lián)合頭孢克洛治療小兒急性細(xì)菌性腸炎效果確切,顯著改善細(xì)菌腸炎引起的發(fā)熱、大便次數(shù)多等癥狀,各炎癥反應(yīng)顯著降低。

Objective To explore the clinical study of Bacillus Licheniformis Granules, Live combined with cefaclor in treatment of acute bacterial enteritis in children. Methods Children (80 cases) with acute bacterial enteritis in children in Nantong Haimen People's Hospital from January 2022 to November 2022 were randomly divided into control (40 cases) and treatment (40 cases) group. Children in the control group were po administered with Cefaclor for Suspension, 0.125 g/time, three times daily. Children in the treatment group were po administered with Bacillus Licheniformis Granules, Live on the basis of the control group, 1/2 bag/time, three times daily. Children in two groups were treated for 5 d. After treatment, the clinical evaluation was evaluated, and the improvement time of symptoms, WBC and NE levels in peripheral blood, the levels of CK-MB, SAA, PCT and CRP, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group (97.51%) was significantly higher than that of the control group (82.5%, P < 0.05). After treatment, the time of improvement of symptoms in the treatment group was earlier than that in the control group (P < 0.05). After treatment, the levels of WBC, NE, CK-MB, SAA, PCT and CRP in peripheral blood in two groups were significantly decreased (P < 0.05), and the levels of these indexes in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the incidence of adverse reactions in the treatment group was 7.51%, which was significantly lower than that in the control group (17.50%, P < 0.05). Conclusion Bacillus Licheniformis Granules, Live combined with cefaclor in treatment of acute bacterial enteritis in children is effective, and can iimprove fever and fecal frequency caused by bacterial enteritis, and the inflammatory reaction is significantly reduced.

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