目的 探探討滋補生發(fā)片聯(lián)合米諾地爾搽劑治療男性雄激素性脫發(fā)的臨床療效。方法 選取2020年1月-2021年6月在西寧市第一人民醫(yī)院整形美容科就診的100例男性雄激素性脫發(fā)患者,按照隨機數(shù)字表法將所有患者分為對照組和治療組,每組各50例。對照組外涂米諾地爾搽劑,1 mL/次,2次/d。治療組患者在對照組治療的基礎(chǔ)上口服滋補生發(fā)片,6~8片/次,3次/d。4周為1個療程,兩組共治療6個療程。觀察兩組的臨床療效,比較兩組的脫發(fā)、瘙癢、油膩、鱗屑中醫(yī)證候積分和毛發(fā)生長情況。結(jié)果 治療后,治療組總有效率為94%,對照組總有效率76%,治療組療效優(yōu)于對照組(P<0.05)。治療后,兩組患者脫發(fā)、瘙癢、油膩、鱗屑積分均顯著降低(P<0.05);且治療組脫發(fā)、瘙癢、油膩、鱗屑積分較對照組各項積分也明顯降低(P<0.05)。治療后,治療組的毛發(fā)生長速度、生長長度較對照組明顯升高(P<0.05)。結(jié)論 滋補生發(fā)片聯(lián)合米諾地爾搽劑治療男性雄激素性脫發(fā)療效更好,可改善脫發(fā)、瘙癢、油膩、鱗屑癥狀,促進毛發(fā)生長。

Objective To investigation of the clinical efficacy of Zibu Shengfa Tablets combined with Minoxidil Liniment in treatment of male androgenetic alopecia. Methods Male patients (100 cases) with androgenetic alopecia in Xining First People's Hospital from January 2020 to June 2021 were divided into control and treatment groups according to the random number table method, and each group had 50 cases. Patients in the control group were externally applied with Minoxidil liniment, 1 mL/time, twice daily. Patients in the treatment group were po administered with Zibu Shengfa Tablets on the basis of the control group, 6-8 tablets/time, three times daily. Four weeks is a course of treatment, and patients in two groups were treated for 6 courses. After treatment, the clinical efficacies were evaluated, and traditional Chinese medicine syndrome scores of hair loss, itching, greasy, and scaling, and the hair growth status in two groups were compared. Results After treatment, total effective rate of the treatment group was 94%, while the total effective rate of the control group was 76%, and the therapeutic effect of the treatment group washigher than that of the control group (P < 0.05). After treatment, the scores of hair loss, itching, greasiness, and scales in two groups were significantly reduced (P < 0.05). Moreover, the scores for hair loss, itching, oiliness, and scales in the treatment group had significantly lower compared to the control group (P < 0.05). After treatment, the hair growth rate and length of the treatment group were significantly increased compared to the control group (P < 0.05). Conclusion Zibu Shengfa Tablets combined with Minoxidil Liniment has clinical effect in treatment of male androgenetic alopecia, can improve symptoms of hair loss, itching, greasy, and scaling, promote hair growth.

R986