檸檬酸因價廉易得,具有良好的生物相容性、生物可降解性和多功能性受到了廣泛關注,已經(jīng)發(fā)展出了眾多的檸檬酸基生物材料,并在藥物遞送系統(tǒng)取得實際進展。總結了檸檬酸在遞送基因治療藥物、蛋白質治療藥物、免疫治療藥物、化學治療藥物中的研究進展,希望檸檬酸在藥物遞送系統(tǒng)得到進一步的研究發(fā)展。

Citric acid has received widespread attention due to its low cost, easy availability, good biocompatibility, biodegradability, and versatility, also numerous citric acid-based biomaterials have been developed, and has made practical progress in drug delivery systems. This article summarizes the research progress of citric acid in delivering gene therapy drugs, protein therapy drugs, immunotherapy drugs, and chemotherapy drugs, hoping for further research and development of citric acid in drug delivery systems.

R944

海南省重點研發(fā)項目(ZDYF2023SHFZ140)