腦梗死是人類第三大死因和第一大致殘原因，如何提高防治腦梗死的療效成為社會廣泛關注的焦點。白藜蘆醇屬于二苯乙烯類多酚，具有廣泛的生物活性，可通過抑制炎癥反應、抗氧化應激反應、增強細胞自噬和能量代謝、促進突觸生長、降低腦缺血區(qū)神經(jīng)細胞凋亡、保護血腦屏障的功能和結構等途徑發(fā)揮防治腦梗死的作用。對白藜蘆醇防治腦梗死的作用機制進行綜述，為白藜蘆醇臨床治療腦梗死提供新思路。

Cerebral infarction is the third leading cause of death and primary cause of disability in humans, and how to improve the efficacy of cerebral infarction has become a widespread focus of attention in society. Resveratrol is a kind of stilbene polyphenol, which has wide activities, and plays a role in prevention and treatment of ischemic stroke by inhibiting inflammatory response, antioxidant stress response, enhancing autophagy and energy metabolism, promoting synaptic growth, reducing neuronal apoptosis in cerebral ischemia area, and protecting the function and structure of blood-brain barrier. This article reviews mechanism of resveratrol in prevention and treatment of cerebral infarction, and provides new ideas for treatment of cerebral infarction with resveratrol.

R285.5

重慶市衛(wèi)生健康委醫(yī)學科研項目（2023WSJK017）