目的 觀察散風(fēng)通竅滴丸聯(lián)合氯雷他定片治療兒童過敏性鼻炎的臨床療效。方法 選取2021年12月—2022年11月在茂名市人民醫(yī)院診療的100例肺經(jīng)伏熱型過敏性鼻炎患兒，按照隨機(jī)數(shù)字表法將患兒分為對照組和治療組，各50例。對照組患兒服用氯雷他定片，1次/d，12歲以上和體質(zhì)量＞30 kg，1片/次；12歲及以下和體質(zhì)量≤30 kg，0.5片/次。治療組患兒在對照組基礎(chǔ)上口服散風(fēng)通竅滴丸，10丸/次，3次/d。兩組患兒均治療3周。觀察兩組的臨床療效，比較兩組的鼻炎癥狀、血清免疫因子指標(biāo)、炎癥因子水平。結(jié)果 治療后，治療組患兒的總有效率為88.00%，明顯高于對照組的總有效率80.00%，差異有統(tǒng)計學(xué)意義（P＜0.05）。治療后，兩組患兒鼻塞、鼻癢、噴嚏、流涕評分均顯著降低（P＜0.05），且治療后治療組患兒鼻塞、鼻癢、噴嚏、流涕評分明顯低于對照組，差異有統(tǒng)計學(xué)意義（P＜0.05）。治療后，兩組患兒血清免疫球蛋白（Ig）A、IgE、IgM水平均顯著下降（P＜0.05），且治療組的血清IgA、IgE、IgM水平均低于對照組，差異具有統(tǒng)計學(xué)意義（P＜0.05）。兩組患兒血清白細(xì)胞介素（IL）-4、IL-6、腫瘤壞死因子-α（TNF-α）水平均顯著下降，IL-10水平升高（P＜0.05），且治療組的血清IL-4、IL-6、TNF-α水平均低于對照組，IL-10水平高于對照組，差異具有統(tǒng)計學(xué)意義（P＜0.05）。結(jié)論 散風(fēng)通竅滴丸聯(lián)合氯雷他定片治療兒童過敏性鼻炎療效顯著，可改善臨床癥狀，降低免疫因子指標(biāo)，改善全身炎癥反應(yīng)。

Objective To observe the effectiveness of Sanfeng Tongjiao Pills combined with Loratadine Tablets in treatment of allergic rhinitis in children. Methods Children (100 cases) with allergic rhinitis in Maoming People’s Hospital from December 2021 to November 2022 were divided into control and treatment groups according to the random number table method, and each group had 50 cases. Children in the control group were po administered with Loratadine Tablets, once daily, over 12 years old and with a body mass greater than 30 kg, 1 tablet/time; 12 years old and below, with a body mass ≤ 30 kg, 0.5 tablet/time. Children in the treatment group were po administered with Sanfeng Tongjiao Pills on the basis of the control group, 10 pills/time, three times daily. Children in two groups were treated for 3 weeks. After treatment, the clinical efficacies were evaluated, and rhinitis symptom, serum immune factor indicators, and the levels of inflammatory factors in two groups were compared. Results After treatment, the total effective rate of children in the treatment group was 88.00%, significantly higher than 80.00% in the control group, with a statistically significant difference (P< 0.05). After treatment, the scores of nasal congestion, itching, sneezing, and runny nose in two groups were significantly decreased (P < 0.05), and the scores of nasal congestion, itching, sneezing, and runny nose in the treatment group were significantly lower than those in the control group, with a statistically significant difference (P< 0.05). After treatment, the serum levels of IgA, IgE, and IgM in two groups of patients were significantly decreased (P < 0.05), and the serum levels of IgA, IgE, and IgM in the treatment group were lower than those in the control group, with statistical significance (P < 0.05). The serum levels of IL-4, IL-6, and TNF-α in two groups were significantly decreased, while the serum levels of IL-10 in two groups were increased (P < 0.05). The serum levels of IL-4, IL-6, and TNF-α in the treatment group were lower than those in the control group, but the serum levels of IL-10 in the treatment group were higher than those in the control group, with statistical significance (P< 0.05). Conclusion Sanfeng Tongjiao Pills combined with Loratadine Tablets has better efficacy in treatment of allergic rhinitis in children, can improve clinical symptoms, reduce immune factor indicators, and improve systemic inflammatory response.

R985；R987