目的 探討甘露聚糖肽聯(lián)合咖啡酸片治療白細胞減少癥的臨床療效。方法 選取2021年3月—2023年3月在鄂州市中心醫(yī)院治療的98例白細胞減少癥患者，隨機分為對照組（49例）和治療組（49例）。對照組口服咖啡酸片，0.2 g/次，3次/d。在對照組基礎(chǔ)上，治療組口服甘露聚糖肽片，10 mg/次，3次/d；兩組連續(xù)服藥28 d。觀察兩組患者臨床療效，比較治療前后兩組患者癥狀改善時間，T淋巴細胞亞群、白細胞指標，血清炎性因子白細胞介素-6（IL-6）、粒細胞集落刺激因子（G-CSF）、腫瘤壞死因子-α（TNF-α）和白細胞介素-8（IL-8）水平。結(jié)果 治療后，治療組患者臨床有效率（97.96%）明顯高于對照組（83.67%，P＜0.05）。治療后，治療組癥狀改善時間均早于對照組（P＜0.05）。治療后，兩組患者CD3^＋、CD4^＋、CD4^＋/CD8^＋、WBC指標均明顯升高（P＜0.05），且治療組這些指標明顯高于對照組（P＜0.05）。治療后，兩組血清炎性因子G-CSF明顯升高，而IL-6、TNF-α和IL-8水平均明顯降低（P＜0.05），且治療組明顯好于對照組（P＜0.05）。結(jié)論 咖啡酸片與甘露聚糖肽協(xié)同治療白細胞減少癥效果確切，能對患者臨床癥狀有效改善，使機體免疫能力增強，并能減弱炎性反應的能力。

Objective To explore the clinical study of mannatide combined with Caffeic Acid Tablets in treatment of leukopenia. Methods Patients (98 cases) with leukopenia in Ezhou Central Hospital from March 2021 to March 2023 were randomly divided into control (49 cases) and treatment (49 cases) group. Patients in the control group were po administered with Caffeic Acid Tablets, 0.2 g/time, three times daily. Patients in the treatment group were po administered with Mannatide Tablets on the basis of the control group, 10 mg/time, three times daily. Patients in two groups were treated for 28 d. After treatment, the clinical evaluation was evaluated, and the improvement time of symptom, the T lymphocyte subpopulations and white blood cell indicators, the levels of serum IL-6, G-CSF, and TNF-α, IL-8 in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group (97.96%) was significantly higher than that of the control group (83.67%, P < 0.05). After treatment, the time of symptom improvement in the treatment group was earlier than that in the control group (P < 0.05). After treatment, the indexes of CD3⁺, CD4⁺, CD4⁺/CD8⁺ and WBC in two groups were significantly increased (P < 0.05), and these indexes in the treatment group were significantly higher than those in the control group (P < 0.05). After treatment, the levels of serum inflammatory factors G-CSF were significantly increased, while the levels of IL-6, TNF-α and IL-8 were significantly decreased in two groups (P < 0.05), and these indicators in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion Caffeic Acid Tablets combined with Mannatide Tablets is effective in treatment of leukopenia, which can effectively improve the clinical symptoms, enhance the body immunity and weaken the ability of inflammatory reaction.

R973

湖北省衛(wèi)生和計劃生育委員會項目資助(WJ2019M072)