活性多肽是美洲大蠊中主要的藥用成分，具有廣泛的藥理活性。近年來，相關領域的學者陸續(xù)發(fā)現(xiàn)了來源于美洲大蠊的單組分活性多肽，如periplanetasin-2、periplanetasin-4、美洲大蠊防御素（PaDefensins）、periplanetasin-5、Pa-THY1、短神經肽（sNPF）。對美洲大蠊多肽的抗微生物作用、抗腫瘤作用、促傷口愈合作用和神經調節(jié)作用進行了綜述，以期為美洲大蠊多肽類藥物的篩選、結構改造以及新藥開發(fā)提供參考。

Active peptides are the main medicinal components in Periplaneta americana, and have extensive pharmacological activity. In recent years, scholars in related fields have successively discovered single-component active peptides derived from P. americana, such as periplanetasin-2, periplanetasin-4, PaDefensins, periplanetasin-5, Pa-THY1, and short neuropeptide F (sNPF). This article reviews the antimicrobial effect, anti-tumor effect, wound healing promotion, and neuromodulatory effect of P. americana peptides, in order to provide reference for the screening, structural modification, and new drug development of P. americana peptide drugs.

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國家自然科學基金面上項目(62276191);國家自然科學基金青年項目(31700086)