我國骨質(zhì)疏松癥的患病率高，是老年患者致殘和致死的主要原因之一。葛根素是葛根中主要活性成分，可促進成骨細胞的增殖分化、抑制骨吸收和破骨細胞的分化形成、促進骨髓間充質(zhì)干細胞向成骨分化、發(fā)揮雌激素樣作用。綜述了葛根素防治骨質(zhì)疏松癥的作用機制研究進展，為深入開展葛根素治療骨質(zhì)疏松癥的基礎研究和新藥開發(fā)提供參考。

The prevalence of osteoporosis in China is high, and is one of the main causes of disability and death in elderly patients. Puerarin is the main active ingredient in Puerariae Radix, which can promote the proliferation and differentiation of osteoblasts, inhibit bone resorption and osteoclast differentiation, promote bone marrow mesenchymal stem cells to differentiate into osteoblasts, and exert estrogen like effects. This article reviews the research progress on mechanism of puerarin in preventing and treating osteoporosis, providing reference for further basic research and new drug development of puerarin in treating osteoporosis.

R982

河南省中醫(yī)藥科學研究專項課題（2022ZY1137）