目的 探討丹膝顆粒聯(lián)合曲克蘆丁治療急性腦梗死恢復(fù)期的臨床療效。方法 選取2018年6月—2023年6月國家電網(wǎng)公司北京電力醫(yī)院腦神經(jīng)內(nèi)科收治的120例急性腦梗死恢復(fù)期患者，按照隨機(jī)數(shù)字表法將所有患者分為對照組和治療組，每組各60例。對照組患者靜脈滴注曲克蘆丁氯化鈉注射液，0.48 g/次，1次/d。治療組在對照組的治療基礎(chǔ)上口服丹膝顆粒，1袋/次，3次/d。兩組用藥20 d觀察治療情況。觀察兩組臨床療效，比較兩組癥狀好轉(zhuǎn)時間、神經(jīng)行為認(rèn)知狀態(tài)檢查表（NCSE）評分、日常生活活動能力量表（ADL）評分、脂蛋白相關(guān)磷脂酶A2（Lp-PLA2）、神經(jīng)元特異性烯醇化酶（NSE）、腦源性神經(jīng)營養(yǎng)因子（BDNF）、同型半胱氨酸（Hcy）水平及不良反應(yīng)情況。結(jié)果 治療后，治療組總有效率是96.67%，顯著高于對照組的83.33%（P＜0.05）。治療后，治療組頭暈、眩暈、肢體麻木、中樞性面癱好轉(zhuǎn)時間均顯著短于對照組（P＜0.05）。治療后，兩組NCSE評分、ADL評分均顯著高于同組治療前（P＜0.05）；且治療后，治療組NCSE評分、ADL評分高于對照組（P＜0.05）。治療后，兩組Lp-PLA2、NSE、Hcy水平均顯著降低，而BDNF水平顯著升高（P＜0.05）；治療后治療組Lp-PLA2、NSE、Hcy水平低于對照組，而BDNF水平高于對照組（P＜0.05）。治療后，治療組不良反應(yīng)發(fā)生率是5.01%，顯著低于對照組的13.33%（P＜0.05）。結(jié)論 丹膝顆粒聯(lián)合曲克蘆丁治療腦梗死恢復(fù)期具有較好的臨床療效，顯著提高患者神經(jīng)行為認(rèn)知能力和日常活動能力，降低機(jī)體炎癥反應(yīng)，值得臨床借鑒應(yīng)用。

Objective To investigate the therapeutic effect of Danxi Granules combined with troxerutin in treatment of convalescent period of acute cerebral infarction. Methods A total of 120 patients in the convalescence stage of acute cerebral infarction admitted to the Department of Neurology of State Grid Corporation Beijing Electric Power Hospital from June 2018 to June 2023 were selected, and all patients were divided into control group and treatment group according to random number table method, with 60 cases in each group. Patients in the control group were iv administered with Troxerutin and Sodium Chloride Injection, 0.48 g/time, once daily. Patients in the treatment group were po administered with Danxi Granules on the basis of the control group, 1 bag/time, three times daily. The two groups were treated for 20 d to observe the treatment. The clinical efficacy of the two groups was observed. Symptom improvement time, neurobehavioral cognitive status checklist (NCSE) score, Activities of daily Living Scale (ADL) score, lipoprotein-associated phospholipase A2 (Lp-PLA2), neuron-specific enolase (NSE), brain-derived neurotrophic factor (BDNF), homocysteine (Hcy) level and adverse reactions were compared between two groups. Results After treatment, the total effective rate of the treatment group was 96.67%, which was significantly higher than that of the control group (83.33%, P < 0.05). After treatment, the improvement time of dizziness, vertigo, limb numbness and central facial paralysis in treatment group was significantly shorter than that in control group (P < 0.05). After treatment, NCSE score and ADL score in two groups were significantly higher than before treatment (P < 0.05). After treatment, NCSE scores and ADL scores in treatment group were higher than those in control group (P < 0.05). After treatment, the levels of Lp-PLA2, NSE and Hcy in both groups were significantly decreased, but the levels of BDNF were significantly increased (P < 0.05). After treatment, the levels of Lp-PLA2, NSE and Hcy in treatment group were lower than those in control group, but the levels of BDNF were higher than those in control group (P < 0.05). After treatment, the incidence of adverse reactions in treatment group was 5.01%, which was significantly lower than that in control group (13.33%, P < 0.05). Conclusion Danxi Granules combined with troxerutin has good clinical effect in treatment of convalescent period of acute cerebral infarction, and can significantly improve the neurobehavioral cognitive ability and daily activity ability of patients, and reduce the inflammatory response of the body, which is worthy of clinical application.

R971

北京市科技計(jì)劃項(xiàng)目（Z171100001017103）