目的 探討保和丸聯(lián)合復(fù)方消化酶膠囊治療功能性消化不良的臨床療效。方法 選取2018年3月—2022年12月重慶市中醫(yī)院收治的78例功能性消化不良患者，按隨機(jī)數(shù)字表法將所有患者分為對照組和治療組，每組各39例。對照組飯后口服復(fù)方消化酶膠囊，2粒/次，3次/d。治療組在對照組基礎(chǔ)上口服保和丸，2丸/次，2次/d。兩組療程均為4周。觀察兩組的臨床療效，比較治療前后兩組主要癥狀積分、功能性消化不良生存質(zhì)量量表（FDDQL）評分、簡明尼平消化不良指數(shù)（SF-NDI）評分及胃排空指標(biāo)。結(jié)果 治療后，治療組患者總有效率是97.44%較之對照組的79.49%顯著提高（P＜0.05）。治療后，兩組餐后飽脹不適、上腹痛、早飽感、上腹燒灼感積分及其總積分均顯著降低（P＜0.05）；且治療后以治療組降低更顯著（P＜0.05）。治療后，兩組患者FDDQL評分均顯著增加，而SF-NDI評分均顯著下降（P＜0.05）；且均以治療組改善更顯著（P＜0.05）。治療后，兩組胃半排空時(shí)間均顯著縮短，胃竇收縮幅度及收縮頻率均顯著增加（P＜0.05）；且均以治療組改善更顯著（P＜0.05）。結(jié)論 保和丸聯(lián)合復(fù)方消化酶膠囊治療功能性消化不良的整體療效確切，能安全有效地減輕患者癥狀，促進(jìn)胃排空，改善生活質(zhì)量。

Objective To explore the clinical efficacy of Baohe Pills combined with Compound Digestive Enzyme Capsules in treatment of functional dyspepsia. Methods A total of 78 patients with functional dyspepsia admitted to Chongqing Hospital of Traditional Chinese Medicine from March 2018 to December 2022 were selected and divided into control group and treatment group according to random number table method, with 39 cases in each group. Patients in the control group were po administered with Compound Digestive Enzyme Capsules, 2 grains/time, three times daily. Patients in the treatment group were po administered with Baohe Pills on the basis of the control group, 2 pills/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the scores of major symptoms, Functional dyspepsia Quality of Life Scale (FDDQL), concise nipine dyspepsia index (SF-NDI) and gastric emptying indexes were compared between the two groups before and after treatment. Results After treatment, the total effective rate of the treatment group was 97.44%, which was significantly higher than that of the control group (79.49%, P < 0.05). After treatment, the scores of postprandial fullness and discomfort, epigastric pain, early satiety and epigastric burning were significantly decreased in both groups (P < 0.05). After treatment, the reduction was more significant in the treatment group (P < 0.05). After treatment, FDDQL scores were significantly increased in both groups, while SF-NDI scores were significantly decreased in both groups (P < 0.05). The improvement was more significant in the treatment group (P < 0.05). After treatment, the gastric half-emptying time was significantly shortened, and the contraction amplitude and frequency of gastric antrum were significantly increased in both groups (P < 0.05). The improvement was more significant in the treatment group (P < 0.05). Conclusion Baohe Pills combined with Compound Digestive Enzyme Capsules has a definite overall therapeutic effect in treatment of functional dyspepsia, and can safely and effectively reduce the symptoms of patients, promote gastric emptying and improve the quality of life.

R975