目的 探討小兒清熱利肺口服液聯(lián)合頭孢克肟顆粒治療兒童急性支氣管炎的臨床效果。方法 選取2021年1月—2022年12月北京市通州區(qū)婦幼保健院收治的96例急性支氣管炎患兒，根據(jù)隨機(jī)數(shù)字表法將所有患兒分為對(duì)照組和治療組，各48例。對(duì)照組溫水沖服頭孢克肟顆粒，2次/d，每次3.0 mg/kg，體質(zhì)量≥30 kg患兒100 mg/次。治療組在對(duì)照組基礎(chǔ)上口服小兒清熱利肺口服液，3次/d，1～2歲：5 mL/次，3～5歲：10 mL/次，6歲及以上：15 mL/次。兩組患兒連續(xù)治療7 d。比較兩組的臨床療效、主要癥狀消退時(shí)間、呼吸功能、血清指標(biāo)。結(jié)果 治療后，治療組的總有效率明顯高于對(duì)照組（P＜0.05）。治療后，治療組發(fā)熱、咳嗽、咯痰、肺啰音消退時(shí)間均明顯短于對(duì)照組（P＜0.05）。治療后，兩組的潮氣量顯著升高，呼吸比、呼吸頻率顯著降低（P＜0.05）；治療組的潮氣量高于對(duì)照組，呼吸比、呼吸頻率低于對(duì)照組（P＜0.05）。治療后，兩組血清白細(xì)胞介素-2（IL-2）水平顯著升高，血清C反應(yīng)蛋白（CRP）、腫瘤壞死因子-α（TNF-α）水平顯著降低（P＜0.05）；治療組的血清IL-2水平高于對(duì)照組，血清CRP、TNF-α水平低于對(duì)照組（P＜0.05）。結(jié)論 小兒清熱利肺口服液聯(lián)合頭孢克肟顆?？商岣邇和毙灾夤苎椎寞熜?，改善患兒癥狀，提高呼吸功能，減輕炎癥反應(yīng)。

Objective To investigate the clinical effect of Xiaoer Qingre Lifei Oral Liquid combined with Cefixime Granules in treatment of acute bronchitis in children. Methods Children (96 cases) with acute bronchitis in Beijing Tongzhou Maternal and Child Health Hospital from January 2021 to December 2022 were divided into control and treatment groups according to random number table method, and each group had 48 cases. Children in the control group were po administered with Cefixime Granules, twice daily, each dose was 3.0 mg/kg, for children with body weight ≥ 30 kg with the dose 100 mg/time. Children in the treatment group were po administered with Xiaoer Qingre Lifei Oral Liquid on the basis of the control group, three times daily, 1 — 2 years old: 5 mL/time, 3 — 5 years old: 10 mL/time, 6 years old and above: 15 mL/time. Children in two groups were treated for 7 d. The clinical efficacies, resolution time of main symptoms, respiratory function, and the serum factors in two groups were compared. Results After treatment, the total effective rate in the treatment group was significantly higher than that in the control group (P < 0.05). After treatment, the regression time of fever, cough, phlegm, and pulmonary rales in the treatment group was significantly shorter than those in the control group (P < 0.05). After treatment, the tidal volume in two groups was significantly increased, but the respiratory ratio and respiratory frequency in two groups were significantly decreased (P < 0.05), and the tidal volume in the treatment group was higher than that in the control group, but the respiratory ratio and respiratory frequency were lower than those in the control group (P < 0.05). After treatment, the serum levels of IL-2 were significantly increased, but the serum levels of CRP and TNF-α were significantly decreased (P < 0.05). And the serum levels of IL-2 in the treatment group was higher than that in the control group, but the serum levels of CRP and TNF-α were lower than those in the control group (P < 0.05). Conclusion Xiaoer Qingre Lifei Oral Liquid combined with Cefixime Granules can improve the therapeutic effect of acute bronchitis in children, improve the efficiency of symptom improvement, improve respiratory function, and reduce the degree of inflammation.

R974；R985

北京市中醫(yī)藥科技發(fā)展資金項(xiàng)目（QN-2020-10）