[關(guān)鍵詞]
[摘要]
目的 探討糖脈康顆粒聯(lián)合度拉糖肽注射液治療2型糖尿病的臨床效果。方法 選取2021年5月—2023年4月在北京市第六醫(yī)院收治的102例2型糖尿病患者,根據(jù)計算機(jī)隨機(jī)排列將所有患者分為對照組和治療組,各包括51例。對照組給予度拉糖肽注射液,起始劑量1次/周,1支/次,根據(jù)血糖水平調(diào)整劑量,維持劑量1次/周,1~2支/次。治療組在對照組基礎(chǔ)上口服糖脈康顆粒,3次/d,1袋/次。兩組在治療3個月后分析療效。比較兩組患者的臨床療效、血糖指標(biāo)、血糖波動情況、血管內(nèi)皮功能和血清指標(biāo)。結(jié)果 治療后,治療組的總有效率高達(dá)92.16%,明顯高于對照組的76.47%(P<0.05)。治療后,兩組患者的空腹血糖(FBG)、糖化血紅蛋白(HbA1c)均顯著下降(P<0.05)。治療后,兩組的平均血糖波動幅度、血糖標(biāo)準(zhǔn)差、餐后血糖波動幅度明顯降低(P<0.05),且治療組的平均血糖波動幅度、血糖標(biāo)準(zhǔn)差、餐后血糖波動幅度均明顯低于對照組(P<0.05),兩組的血管內(nèi)皮功能指數(shù)(FMD)均顯著升高(P<0.05),治療組的FMD明顯高于對照組(P<0.05)。治療后,兩組的血清內(nèi)脂素(visfatin)、內(nèi)皮素-1(ET-1)水平顯著降低(P<0.05),治療組的血清visfatin、ET-1水平低于對照組(P<0.05)。結(jié)論 糖脈康顆粒聯(lián)合度拉糖肽注射液可提高2型糖尿病的療效,有效降低血糖水平和血糖波動,改善血管內(nèi)皮功能。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Tangmaikang Granules combined with Dulaglutide Injection in treatment of type 2 diabetes mellitus. Methods Patients (102 cases) with type 2 diabetes mellitus in Beijing Sixth Hospital from May 2021 to April 2023 were divided into control and treatment groups according to computer random arrangement method, and each group had 51 cases. Patients in the control group were given Dulaglutide Injection, the initial dose was 1 dose/time, once weekly, and the dose was adjusted according to the blood glucose level, and the maintenance dose was once weekly, and the dose was 1 — 2 dose/time. Patients in the treatment group were po administered with Tangmaikang Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 3 months. The clinical efficacies, blood glucose indexes, blood glucose fluctuation, vascular endothelial function indexes, and serum indexes in two groups were compared. Results After treatment, the total effective rate of the treatment group was 92.16%, which was significantly higher than that of the control group (76.47%, P < 0.05). After treatment, FBG and HbA1c in two groups were significantly decreased (P < 0.05). After treatment, the mean blood glucose fluctuation range, blood glucose standard deviation and postprandial blood glucose fluctuation range of two groups were significantly reduced (P < 0.05), and the mean blood glucose fluctuation range, blood glucose standard deviation, and postprandial blood glucose fluctuation range of the treatment group were significantly lower than those of the control group (P < 0.05). After treatment, FMD in two groups was significantly increased (P < 0.05), and FMD in the treatment group was significantly higher than that in the control group (P < 0.05). After treatment, the serum levels of visfatin and ET-1 in two groups were significantly decreased (P < 0.05), and the serum levels of visfatin and ET-1 in the treatment group were lower than those in the control group (P < 0.05). Conclusion Tangmaikang Granules combined with Dulaglutide Injection can improve the therapeutic effect of type 2 diabetes mellitus, effectively reduce blood glucose level and blood glucose fluctuation, improves vascular endothelial function.
[中圖分類號]
R977
[基金項(xiàng)目]
北京市東城區(qū)衛(wèi)生科技計劃項(xiàng)目[東衛(wèi)健研(2019)]