急性肝損傷是一種嚴(yán)重的疾病，其發(fā)病機(jī)制和影響因素多種多樣，其中藥物治療是目前急性肝損傷的主要治療方法。槲皮素為黃酮醇類化合物，可通過抗炎、抗氧化應(yīng)激反應(yīng)、抗肝纖維化、抗細(xì)胞凋亡、增強(qiáng)細(xì)胞自噬、抑制轉(zhuǎn)運(yùn)體NTCP的表達(dá)降低膽汁酸重吸收、調(diào)節(jié)肝臟脂質(zhì)代謝，多途徑減輕肝損傷，發(fā)揮肝保護(hù)作用?？偨Y(jié)了槲皮素防治急性肝損傷的作用機(jī)制，為急性肝損傷治療提供參考。

Acute liver injury is a serious disease with diverse pathogenesis and influencing factors. Drug therapy is currently the main treatment method for acute liver injury. Quercetin is a flavonol, and can alleviate liver injury through multiple pathways and exert liver protective effects through anti-inflammatory, anti-oxidative stress, anti-liver fibrosis, anti-apoptosis, enhancing autophagy, inhibiting the expression of transporter NTCP to reduce bile acid reabsorption, regulating liver lipid metabolism. This article summarizes the mechanism of quercetin in prevention and treatment of acute liver injury, providing reference for the treatment of acute liver injury.

R975

重慶市科衛(wèi)聯(lián)合醫(yī)學(xué)科研項(xiàng)目（2018MSXM089）