目的 探討槐杞黃顆粒聯(lián)合艾曲泊帕乙醇胺片治療兒童難治性免疫性血小板減少癥的臨床效果。方法 選取2020年1月—2022年7月河北省兒童醫(yī)院收治的60例兒童難治性免疫性血小板減少癥患兒，將60例患兒用隨機數(shù)字表法分為對照組（30例）和治療組（30例）。對照組口服艾曲泊帕乙醇胺片，初始劑量25 mg/d，隨后根據(jù)血小板計數(shù)（PLT）調(diào)整劑量。治療組在對照組基礎(chǔ)上開水沖服槐杞黃顆粒，1袋/次，2次/d。兩組均治療6個月。比較兩組的臨床療效、PLT和免疫功能。結(jié)果 治療后，治療組總有效率顯著高于對照組（P＜0.05）。治療后，兩組PLT較治療前均顯著升高（P＜0.05），且治療組的PLT高于對照組（P＜0.05）。治療后，兩組CD3⁺、CD4⁺、CD4⁺/CD8⁺水平均明顯升高，CD8⁺明顯降低（P＜0.05）；治療后，治療組CD3⁺、CD4⁺、CD4⁺/CD8⁺水平均高于對照組，CD8⁺低于對照組（P＜0.05）。結(jié)論 槐杞黃顆粒聯(lián)合艾曲泊帕乙醇胺片治療兒童難治性免疫性血小板減少癥具有較好臨床療效，能夠在短期內(nèi)快速提升患兒PLT水平，增強免疫功能。

Objective To explore clinical effect of Huaiqihuang Granules combined with Eltrombopag Olamine Tablets in treatment of refractory immune thrombocytopenia in children. Methods Children (60 cases) with refractory immune thrombocytopenia in Hebei Children’s Hospital from January 2020 to July 2022 were divided into control and treatment groups according to random number tablet method, and each group had 30 cases. Children in the control group were po administered with Eltrombopag Olamine Tablets, the initial dose was 25 mg/d, and then the dose was adjusted based on PLT count. Children in the treatment group were po administered with Huaiqihuang Granules on the basis of the control group, 1 bag/time, twice daily. Patients in two groups were treated for 6 months. The clinical efficacies, PLT, and immune function in two groups were compared. Results After treatment, the total effective rate of the treatment group was significantly higher than that in the control group, with a statistically significant difference (P＜0.05). After treatment, PLT in two groups was significantly higher than that before treatment (P＜ 0.05), and PLT in treatment group was higher than that in control group (P＜ 0.05). After treatment, the levels of CD3⁺, CD4⁺, and CD4⁺/CD8⁺ in two groups were increased, but the levels of CD8⁺ were decreased (P＜0.05). After treatment, the levels of CD3⁺, CD4⁺, and CD4⁺/CD8⁺ in the treatment group were higher than those in the control group, and the levels of CD8⁺ were lower than those in the control group (P＜ 0.05). Conclusion Huaiqihuang Granules combined with Eltrombopag Olamine Tablets has clinical effect in treatment of refractory immune thrombocytopenia in children, can rapidly increase the PLT level of children and enhance immune function.

R973

河北省醫(yī)學(xué)科學(xué)研究課題計劃項目（20190825）