目的 探討桂龍咳喘寧片聯(lián)合布地奈德治療小兒急性支氣管炎的臨床效果。方法 選取2021年3月—2023年3月在運(yùn)城市中心醫(yī)院治療的急性支氣管炎患兒148例，隨機(jī)分為對(duì)照組（74例）和治療組（74例）。對(duì)照組患兒霧化吸入布地奈德混懸液，1 mL加入生理鹽水2 mL，1次/d。治療組患兒在對(duì)照組基礎(chǔ)上口服桂龍咳喘寧片，2次/d，4片/次。兩組患兒均連續(xù)治療7 d。觀察兩組患兒臨床療效，比較治療前后兩組患兒臨床癥狀改善情況及白細(xì)胞計(jì)數(shù)（WBC）、C反應(yīng)蛋白（CRP）和白細(xì)胞介素-17（IL-17）水平。結(jié)果 治療后，治療組總有效率為93.24%，明顯高于對(duì)照組（81.08%，P＜0.05）。治療后，治療組咳嗽消失時(shí)間、體溫恢復(fù)正常時(shí)間和咳痰消失時(shí)間均短于對(duì)照組（P＜0.05）；治療后，兩組WBC、CRP和IL-17水平較治療前明顯降低（P＜0.05），且治療組降低幅度明顯大于對(duì)照組（P＜0.05）。結(jié)論 桂龍咳喘寧片聯(lián)合布地奈德治療小兒急性支氣管炎能幫助患兒快速控制臨床癥狀，降低體內(nèi)的炎癥反應(yīng)，療效令人滿意，且安全性好。

Objective To investigate the therapeutic effect of Guilong Kechuanning Tablets combined with budesonide in treatment of acute bronchitis in children. Methods Children (148 cases) with acute bronchitis in Yuncheng Central Hospital from March 2021 to March 2023 were randomly divided into control (74 cases) and treatment (74 cases) group. Children in the control group were administered with Budesonide Suspension for inhalation, 1 mL added into normal saline 2 mL, once daily. Children in the treatment group were po administered with Guilong Kechuanning tablets on the basis of the control group, 4 tablets/time, twice daily. Children in two groups were treated for 7 d. After treatment, the clinical evaluation was evaluated, and the time of symptom relief, the levels of WBC, CRP and IL-17 in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 93.24%, which was significantly higher than that of the control group (81.08%, P＜0.05). After treatment, the disappearance time of cough, body temperature and sputum in the treatment group were shorter than those in the control group (P＜0.05). After treatment, the levels of WBC, CRP, and IL-17 in both groups were significantly lower than those before treatment (P＜0.05), and the reduction range in the treatment group was significantly greater than that in the control group (P＜0.05). Conclusion Guilong Kechuanning Tablets combined with budesonide in treatment of acute bronchitis in children can help children with acute bronchitis quickly control clinical symptoms and reduce inflammatory reaction in vivo with good efficacy and safety.

R974

山西省衛(wèi)生健康委員會(huì)科研課題（2020188）