瞬時受體電位（TRP）通道是一類主要定位于細(xì)胞膜的非特異性陽離子通道，是多種細(xì)胞和環(huán)境信號的傳感器，激活后可與眾多生理信號通路相互作用，參與多種生理病理過程。Sigma-1受體是一種特異存在于線粒體相關(guān)內(nèi)質(zhì)網(wǎng)膜的分子伴侶蛋白，參與調(diào)控細(xì)胞穩(wěn)態(tài)和細(xì)胞應(yīng)激。TRP通道和Sigma-1受體均廣泛存在于哺乳動物體內(nèi)各組織器官，研究發(fā)現(xiàn)二者之間存在相互作用，參與調(diào)節(jié)不同類型疼痛的發(fā)生、發(fā)展過程。TRP通道和Sigma-1受體對辣椒素誘導(dǎo)的痛覺過敏、內(nèi)源性阿片肽鎮(zhèn)痛效應(yīng)、奧沙利鉑誘導(dǎo)的周圍神經(jīng)病變、外周免疫驅(qū)動的痛覺過敏進行調(diào)控。對TRP通道與Sigma-1受體的相互作用及其調(diào)控疼痛情況進行了總結(jié)。

Transient receptor potential (TRP) channels are a kind of non-specific cation channel mainly residing at plasma membranes, which are sensors for a variety of cellular and environmental signals. Activated TRP channels are involved in various physiological and pathological processes by interacting with many physiological signal pathways. Sigma-1 receptor is a molecular chaperone protein that resides specifically in the mitochondria-associated endoplasmic reticulum membrane, and participated in the modulation of cell homeostasis and cell stress. There is interaction between TRP channels and Sigma-1 receptors, which is involved in regulating the occurrence and development of different types of pain. TRP channels and Sigma-1 receptors regulate capsaicin induced hyperalgesia, endogenous opioid peptide analgesic effects, oxaliplatin induced peripheral neuropathy, and peripheral immune driven hyperalgesia. This article summarizes the interaction between TRP channels and Sigma-1 receptors and their regulation of pain.

R971

甘肅省科技計劃項目（20JR10FA663）