目的 建立采用抑制電導(dǎo)離子色譜法測(cè)定醋酸鈣顆粒中鈣離子的方法。方法 采用Dionex IonPac^TM CS12A色譜柱（250 mm×4 mm），Dionex IonPac^TM CG12A保護(hù)柱（50 mm×4 mm），以0.02 mol/L甲烷磺酸溶液為洗脫液，體積流量1.0 mL/min，柱溫30 ℃，檢測(cè)池溫度35 ℃，電導(dǎo)檢測(cè)器，抑制器為Dionex CDRS 600 4 mm，電流值59 mA，進(jìn)樣體積為25 μL。結(jié)果 鈣在0.002～6.000 μg/mL線性關(guān)系良好（r＝0.999 7），平均回收率為104.6%，RSD值為1.8%。結(jié)論 方法簡(jiǎn)單、專(zhuān)屬性高、準(zhǔn)確可靠，能夠有效地控制醋酸鈣顆粒中鈣離子。

Objective To establish a method of ion chromatography-suppressed conductivity to determine calcium ion in Calcium Acetate Granules.Methods The assay was performed on Dionex IonPac^TM CS12A column (250 mm × 4 mm) with Dionex IonPac^TM CG12A column (50 mm × 4 mm) as guard column. Mobile phase was used as 0.02 mol/L methanesulfonic acid solution. Flow rate was 1.0 mL/min, column temperature was 30 ℃, and detecting pool temperature was 35 ℃. Conductivity detector was used with CDRS 600 4 mm as suppressor, current value was 59 mA, and injection volume was 25 μL. Results Calcium showed good linear relationships of 0.002 -6.000 μg/mL (r＝0.999 7), whose average recovery was 104.6% with RSD values of 1.8%. Conclusion The method is simple, highly specific, accurate and reliable, and can effectively control calcium ion in Calcium Acetate Granules.

R927.1